The involvement of Streptococcus anginosus infection and AID expression in oral cancers

咽峡炎链球菌感染及AID表达与口腔癌的关系

• 批准号: 23659861
• 负责人: KODAMA YOSHITOYO
• 金额: $ 2.5万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659861/
• 关键词: 感染発癌; AID; 口腔細菌; 口腔癌; Streptococcus anginosus; 炎症; S. anginosus; 歯肉上皮細胞; 口腔レンサ球菌

Streptococcus anginosus infection could be closely related with oral squamous cellcarcinoma. Recent studies suggested that the aberrant expression of AID in the epithelial cells could re-sult in the generation of nucleotide alterations in tumor-related genes and possible malignant transforma-tion of the AID-expressing cells. In this study, the involvement of S. anginosus infection and the AID ex-pression in oral cancers was assessed. S. anginosus DNA was frequently detected in the oral squamous cell carcinoma, and the relatively higher AID expressions were observed in the cancerous region. The stimula- tion with S. anginosus antigens could induce the NF-kB activation and AID expression in cultured cell li- nes. Taken together, S. anginosus infection could be closely related with the AID expression in the oral squamous cell carcinoma.

咽峡炎链球菌感染与口腔鳞癌的发生密切相关。 近年来的研究表明，上皮细胞中AID的异常表达可导致肿瘤相关基因的核苷酸改变，并可能导致表达AID的细胞发生恶性转化。在这项研究中，参与S。分析了口腔癌组织中咽峡炎病毒感染和AID表达的关系。S.在口腔鳞状细胞癌组织中，血管紧张素Ⅱ（AID）阳性率最高，癌组织中AID表达相对较高。用S.心绞痛抗原可诱导培养细胞系NF-κ B活化和AID表达。在一起，S。咽峡炎病毒感染可能与口腔鳞癌中AID的表达密切相关。

项目成果

Interface oral health science 2011

• DOI: 10.1007/978-4-431-54070-0
• 发表时间: 2012
• 作者: K. Sasaki;O. Suzuki;N. Takahashi;P. Stashenko;M. Cambridge

The involvement of Streptococcus anginosus infection and AID expression in oral cancers.

口腔癌中咽峡炎链球菌感染和 AID 表达的参与。

• 发表时间: 2014
• 作者: M. Sasaki;K. Iwasaki;Y. Kodama;Y. Shimoyama;T. Ishikawa;Y. Sugiyama;S. Kimura
• 通讯作者: S. Kimura

Maternal transmission of mutans and other oral streptococcal species

变形链球菌和其他口腔链球菌的母体传播

• 发表时间: 2011
• 作者: Otake-Asakawa;A.;Harada-Oikawa;R.;Ohara-Nemoto;Y.;Tanaka;M. and Kimura;S
• 通讯作者: S

Infection of ‘red complex species’ to the plaque of children.

儿童斑块感染“红色复合物”。

• 发表时间: 2014
• 作者: Yu Shimoyama;Misumi Kimura;Yuko Ohara-Nemoto;Takayuki K. Nemoto;Mitsuro Tanaka;Minoru Sasaki;Shigenobu Kimura
• 通讯作者: Shigenobu Kimura

Nested PCR を用いた小児口腔へのPorphyromonas gingivalis 線毛タイプ別感染実態の検討

巢式PCR按菌毛类型检测儿童口腔牙龈卟啉单胞菌感染的实际状况

• 发表时间: 2013
• 作者: Sasaki;M.;Kodama;Y.;Shimoyama;Y.;Kimura;S;下山 佑,木村美澄,佐々木実,根本優子,古玉芳豊,上戸幸美,田中光郎,木村重信
• 通讯作者: 下山 佑,木村美澄,佐々木実,根本優子,古玉芳豊,上戸幸美,田中光郎,木村重信