Regulating Intracellular Dynamics of Metal Nanoparticles by Bioorthogonal Chemical Reactions

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Artificially synthesized nanoparticles have been attracted much attention as novel material for drug delivery. However, little is known about the mechanisms of their accumulation in living cells and of excretion from cells. Especially, the effects of surface chemical properties of nanoparticles on the mechanisms are not clear. In this research, we have synthesized nanoparticles with cyclooctyne structure on the surface, and examined chemical conversion of the surface structures in living cells and direct observation of the reactions. We have successfully demonstrated the first example of controlling intracellular dynamics of the synthesized nanoparticles by modifying their surfaces with organ-homing molecules inside the cells.