Destruction of the multidrug efflux transporter on the plasma membrane by photodynamic treatment

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Photodynamic therapy (PDT) established as a curative treatment for the cancer has acquired anticancer efficacy by producing reactive oxygen species on the plasma membrane or the cytoplasmic organelle. In this study, I employed PDT inducing no remarkable cell injury and investigate whether the PDT can reduce the degree of the resistance of cisplatin- or paclitaxel-resistant HeLa cells.As the results, the cytotoxicity of paclitaxel for the paclitaxel-resistant HeLa cells was unchanged, whereas, the cytotoxicity of cisplatin for the cisplatin-resistant HeLa cells seems to increase. These findings suggest that the PDT is effective item for the reducing resistance of the anticancer drug- resistant cells possessing the cytoplasmic detoxification mechanism such as Glutathione(GSH) or metallothionein(MT) detoxification pathway.