Development of a novel evaluation system for the barriers against drug delivery in stroma and mucus

开发一种新型评价系统，用于基质和粘液中药物输送的障碍

• 批准号: 24650282
• 负责人: USHIDA Kiminori
• 金额: $ 2.5万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24650282/
• 关键词: 蛍光相関分光; 細胞外マトリックス; 間質バリヤ; ドラッグデリバリ; 粘液バリヤ; 抗がん剤; 拡散係数; ムチン; 粘膜バリヤ; 評価系; ドラックデリバリ

A novel measurement system to evaluate the barriers agains drug delivery in extracellular spaces (stroma) and mucus was developed in this project. The standard matrices were the aqueous solutions of hyaluronan and jellyfish mucin (qniumucin) for stroma and mucus, respectively. Several molecules labeled with fluorescent dyes which simulate various drugs traveling through the extracellular spaces and mucus were also synthesized. A measurement instrument for fluoresecnce correlation spectroscopy (FCS) was optimized for the present evaluation.

本项目开发了一种新的测量系统来评估细胞外间隙（基质）和粘液中药物传递的障碍。标准基质分别为透明质酸水溶液和水母黏液（qniumucin）水溶液。用荧光染料标记的几个分子模拟了各种药物在细胞外空间和黏液中的移动。对荧光相关光谱（FCS）测量仪器进行了优化。

项目成果

A Novel Material Mucin Extracted fromm Jellyfishes and a Critical Evaluation of Its Economical Merits in Recycle Operation

从水母中提取的新材料粘蛋白及其回收操作中的经济价值的批判性评价

• 发表时间: 2014
• 期刊: Journal of Life Cycle Assessment, Japan
• 作者: Yamamoto Y;Hyodo I;Takigahira M;Koga Y;Yasunaga M;Harada M;Hayashi T;Kato Y;Matsumua Y;Kiminori Ushida
• 通讯作者: Kiminori Ushida

Visualisation of drug delivery by using high resolution microscopic mass spectrometry

使用高分辨率显微质谱法实现药物输送的可视化

• 发表时间: 2014
• 作者: 安永正浩;古田大;緒方是嗣;古賀宣勝;山本祥之;瀧ヶ平美里;松村保広
• 通讯作者: 松村保広

クラゲ由来ムチン水溶液の表面張力測定

海蜇源粘蛋白水溶液的表面张力测量

• 发表时间: 2014
• 作者: 丑田公規;村上明日香;大畑絢香;五月女佳蓉;小林樹来;杉山みなみ;上田卓典;犬井洋
• 通讯作者: 犬井洋

がん間質の量に応じた抗体・抗がん剤複合体の治療戦略

抗体/抗癌药物复合物的治疗策略取决于癌基质的量

• 发表时间: 2013
• 作者: 安永正浩;眞鍋史乃;松村保広
• 通讯作者: 松村保広

Development of fibrin-targeting CAST (Cancer stromal targeting) diagnosis and therapy

纤维蛋白靶向 CAST（癌症基质靶向）诊断和治疗的发展

• 作者: K. Ushida;Y. Shitara;M. Shirahata;Y. Terada;K. Saotome;安永正浩;安永正浩;安永正浩
• 通讯作者: 安永正浩