Identification of a genetic polymorphism that can predict the effects of resistance exercise training for the prevention of sarcopenia

骨骼肌减少症的特征是骨骼肌质量和功能（强度或性能）随着年龄的增长而逐渐减少。肌少症已成为与身体残疾、代谢综合征和心血管疾病齐名的重大公共卫生问题。抗阻运动训练是公认的限制或预防肌少症最有效的非药物干预手段。然而，先前的研究发现，肌肉质量和力量存在巨大的个体差异。肌肉质量和力量的个体间差异可能是由于环境因素、遗传因素和/或基因-环境相互作用。在这里，我们试图在相对骨骼肌量低的日本老年人中确定与阻力运动训练后骨骼肌质量可训练性相关的遗传多态性。

Sarcopenia is characterized by a progressive decrease of skeletal muscle mass and function (strength or performance) with aging. Sarcopenia has become a highly significant public health problem, physical disability, metabolic syndrome and cardiovascular diseases. Resistance exercise training is well established as the most effective non-pharmacological intervention to restrict or prevent sarcopenia. However, previous studies observed enormous inter-individual variability in muscle mass and strength. Inter-individual variations for muscle mass and strength may be due to environmental factors, genetic factors and/or gene-environment interactions. Here we tried to identify genetic polymorphisms associated with trainability of skeletal muscle mass after resistance exercise training in elderly Japanese people with low relative skeletal muscle mass.