Synthesis of Apatite Nanocrystals Containing Chlorophyll Molecules and the Antibody Immobilization towards Early Cancer Diagnosis

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The detection technique in which cancer cells at early stages can be specifically imaged by highly-biocompatible marker materials has been desired. In this study, biocompatible luminescent inorganic/organic hybrid nanoparticles were prepared in order to detect smaller tumor locations at the cellular sizes. As a result, nucleation reaction of inorganic apatite (or titania) effectively occurred on the end groups of highly-biocompatible dye molecules to successfully obtain the novel hybrid nanoparticles. The ligand molecules that can selectively react with cancer cells were chemically immobilized on the hybrid nanoparticles. The immobilized nanoparticles exhibited nontoxicity and specifically bound to cancer cells to resultantly induce intense orange (or green) luminescence. The hybrid nanoparticles that effectively work on cancer cells will provide novel concepts for non-invasive bioimaging as well as drug therapy for cancer diseases.