Hemostatic mechanism and application ot endoscope of blood coagulation by low temperature atmospheric plasma

低温常压等离子体凝血内镜止血机理及应用

• 批准号: 24654194
• 负责人: KITANO Katsuhisa
• 金额: $ 2.41万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24654194/
• 关键词: 大気圧低温プラズマ; プラズマ医療; 止血; 血液凝固因子; プラズマ止血; 大気圧プラズマ; 内視鏡; がん治療

For blood coagulation by low temperature atmospheric plasma, plasma device for endoscope was developed and its hemostatic mechanism was evaluated. The lethality bleed from femoral vein of mouse was controlled with clarity. The bleed from internal organ with partial ablation was also controlled. By pathology assessment, no damege against body cell was seen. Because the shape of red blood cell was kept in blood clot, it seems that some of blood coagulation factor is triggered and plasma directly activate thrombin activation or fibrinogen degradation.

针对低温大气压等离子体凝固血液的特点，研制了内窥镜用等离子体装置，并对其止血机理进行了评价。小鼠股静脉致死性出血控制清晰。部分消融后内脏出血也得到控制。病理学检查未见体细胞损伤。由于血凝块中红细胞的形状保持不变，似乎是某些凝血因子被触发，血浆直接激活凝血酶活化或纤维蛋白原降解。

项目成果

冷たいプラズマを用いた液中誘起化学反応のバイオ応用～重合から殺菌まで～, 化学と教育,60巻9号

使用冷等离子体在液体中诱导化学反应的生物应用 - 从聚合到灭菌 -，化学与教育，第 60 卷，第 9 期。

• 发表时间: 2012
• 作者: 北野勝久;谷篤史;井川聡;大島朋子;北野勝久
• 通讯作者: 北野勝久

Degeneration of amyloid-s fibrils caused by exposure to low-temperature atmospheric-pressure plasma in aqueous solution

暴露于水溶液中的低温大气压等离子体引起的淀粉样原纤维变性

• 发表时间: 2014
• 期刊: Appl. Phys. Lett
• 作者: Eisuke Takai;Gai Ohashi;Tomonori Yoshida;Karin Margareta Sorgjerd;Tamotsu Zako;Mizuo Maeda;Katsuhisa Kitano and Kentaro Shiraki
• 通讯作者: Katsuhisa Kitano and Kentaro Shiraki

Freezing preservation of the plasma treated water for disinfection treatment in dental and surgical therapies based on the reduced pH method

• 发表时间: 2013
• 作者: K. Kitano;S. Ikawa;A. Tani;Y. Nakashima;Hiromitsu Yamazaki;T. Ohshima;Kazuhiro Kaneko;Masaaki Ito;Takeshi Kuwata;Atsushi Yagishita

Strong bactericidal activity of the plasma treated water for medical application based on the reduced pH method

基于还原pH法的医用等离子处理水的强杀菌活性

• 发表时间: 2014
• 作者: Katsuhisa Kitano;Satoshi Ikawa;Atsushi Tani;Yoichi Nakashima;Tomoko Ohshima
• 通讯作者: Tomoko Ohshima

Plasma photonics

等离子体光子学

• 发表时间: 2013
• 作者: K. Kitano;S. Ikawa;A. Tani;H. Yamazaki;T. Oshima;E. Usui;Y. Momoi;K. Kaneko;M. Ito;T. Kuwata;A. Yagishita;K. Kitano
• 通讯作者: K. Kitano