Formulation of multifunctional bio-interface that aims at application to artificial blood vessel

旨在应用于人造血管的多功能生物界面的制定

• 批准号: 24656404
• 负责人: OUGIZAWA Toshiaki
• 金额: $ 2.58万
• 依托单位: Tokyo Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24656404/
• 关键词: 人工血管; ePTFE; 表面処理; コラーゲン; バイオインターフェース; イオンビーム

It aimed to achieve an artificial blood vessel of 5mm or less in inside diameter. By using a sheet of expanded polytetrafluoroethylene that was a model material of the artificial blood vessel, the improvement of adhesion with collagen that was an intermediate material for adhesion with the endothelial cell was attempted. The anchor effect by cutting the fibril by the surface treatment and making collagen easy to invade the inside of film was important in the adhesion. An increase in the interaction by the introduction of the polarity functional groups with oxygen and an increase in carbon ratio were also important. When the collagen was processed by the ion beam, the composition of amino-acid has changed to remove the amino-acids of weak bonding from the protein. Though the endothelial cell is easily bonded to collagen, it is considered that the adhesion of platelet to collagen changes by the change in the amino-acid composition as an increase in the amount of ion beam irradiation.

它旨在实现内径为5mm或更小的人造血管。通过使用作为人造血管的模型材料的膨胀聚四氟乙烯片，尝试改善与胶原的粘附性，所述胶原是用于与内皮细胞粘附的中间材料。通过表面处理切断原纤维，使胶原易于侵入膜内部，从而产生锚效应，这在粘附中起重要作用。通过引入极性官能团与氧的相互作用的增加和碳比的增加也是重要的。胶原蛋白经离子束处理后，氨基酸组成发生变化，去除了蛋白质中弱键氨基酸。虽然内皮细胞容易与胶原结合，但认为随着离子束照射量的增加，氨基酸组成发生变化，从而血小板与胶原的粘附发生变化。

项目成果

抗血栓性人工血管の開発を目的とした細胞外マトリックスタンパク質の構築

构建细胞外基质蛋白用于抗血栓人工血管的开发

• 发表时间: 2013
• 作者: 西岡宣之;扇澤敏明 ;三重正和;小畠英理
• 通讯作者: 小畠英理

小口径人工血管用延伸テフロンへの表面処理効果とコラーゲン接着

小直径人工血管用拉伸聚四氟乙烯的表面处理效果及胶原蛋白附着力

• 发表时间: 2013
• 作者: 石崎樹久;保山敬一;扇澤敏明;(理研)田中俊行;鈴木嘉昭
• 通讯作者: 鈴木嘉昭