Formulation of multifunctional bio-interface that aims at application to artificial blood vessel

它的目标是实现内径小于等于5毫米的人造血管。利用一层膨胀聚四氟乙烯作为人造血管的模型材料，试图改善胶原蛋白与内皮细胞粘附的中间材料的粘附性。表面处理切断纤维的锚定作用，使胶原蛋白易于侵入膜内，对粘连起重要作用。引入极性官能团与氧的相互作用的增加和碳比的增加也很重要。当胶原蛋白被离子束处理时，氨基酸的组成发生了变化，从蛋白质中去除弱键的氨基酸。虽然内皮细胞很容易与胶原结合，但我们认为随着离子束照射量的增加，血小板对胶原的粘附会随着氨基酸组成的改变而改变。

It aimed to achieve an artificial blood vessel of 5mm or less in inside diameter. By using a sheet of expanded polytetrafluoroethylene that was a model material of the artificial blood vessel, the improvement of adhesion with collagen that was an intermediate material for adhesion with the endothelial cell was attempted. The anchor effect by cutting the fibril by the surface treatment and making collagen easy to invade the inside of film was important in the adhesion. An increase in the interaction by the introduction of the polarity functional groups with oxygen and an increase in carbon ratio were also important. When the collagen was processed by the ion beam, the composition of amino-acid has changed to remove the amino-acids of weak bonding from the protein. Though the endothelial cell is easily bonded to collagen, it is considered that the adhesion of platelet to collagen changes by the change in the amino-acid composition as an increase in the amount of ion beam irradiation.