Models for connecting mechanics at cell and tissue scales

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Because of difficulty in directly measuring forces working in growing tissues, how mechanical forces are regulated for achieving deformation of animal body in their morphogenesis is still not well understood. We have developed a theoretical method for inferring the forces from shape of cells. We verified the accuracy and robustness of the method by performing comparison of our method with laser-ablation experiments, and also comparison among other inference methods. By applying our method to Drosophila epithelial tissues, we compared how mechanical features of cells in respective tissues can results in distinct and characteristic behaviors of the tissues.