Models for connecting mechanics at cell and tissue scales

连接细胞和组织尺度力学的模型

• 批准号: 24657145
• 负责人: ISHIHARA SHUJI
• 金额: $ 2.41万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24657145/
• 关键词: 発生力学; 統計学; 組織力学; ベイズ推定; 発生学; 国際情報交換 フランス; 国際研究者交流; フランス

Because of difficulty in directly measuring forces working in growing tissues, how mechanical forces are regulated for achieving deformation of animal body in their morphogenesis is still not well understood. We have developed a theoretical method for inferring the forces from shape of cells. We verified the accuracy and robustness of the method by performing comparison of our method with laser-ablation experiments, and also comparison among other inference methods. By applying our method to Drosophila epithelial tissues, we compared how mechanical features of cells in respective tissues can results in distinct and characteristic behaviors of the tissues.

由于难以直接测量生长组织中作用的力，如何调节机械力以实现动物体形态发生的变形仍不清楚。我们开发了一种从细胞形状推断力的理论方法。我们通过将我们的方法与激光烧蚀实验进行比较以及与其他推理方法进行比较来验证该方法的准确性和鲁棒性。通过将我们的方法应用于果蝇上皮组织，我们比较了各个组织中细胞的机械特征如何导致组织的独特和特征行为。

项目成果

Estimating Dynamics of Forces during Morphogenesis

估计形态发生过程中力的动力学

• 发表时间: 2012
• 作者: Shizue Ohsawa;Kaoru Sugimura;Kyoko Takino;and Tatsushi Igaki.;S. Ishihara and K. Sugimura.;石原秀至;S. Ishihara and K. Sugimura.;石原秀至,杉村薫;石原秀至,杉村薫;石原秀至;石原秀至;S. Ishihara and K. Sugimura.;S. Ishihara and K. Sugimura.;S. Ishihara and K. Sugimura.
• 通讯作者: S. Ishihara and K. Sugimura.

細胞のかたちから推定する“力”の場

根据细胞形状估计“力”场

• 发表时间: 2013
• 期刊: 実験医学
• 作者: 石原秀至;杉村薫
• 通讯作者: 杉村薫

Mechanical control of cell rearrangements for the developing animal forms

发育中动物形态的细胞重排的机械控制

• 发表时间: 2012
• 作者: Shizue Ohsawa;Kaoru Sugimura;Kyoko Takino;and Tatsushi Igaki.;S. Ishihara and K. Sugimura.;石原秀至;S. Ishihara and K. Sugimura.;石原秀至,杉村薫;石原秀至,杉村薫;石原秀至;石原秀至;S. Ishihara and K. Sugimura.
• 通讯作者: S. Ishihara and K. Sugimura.

Mechanical control of cell rearrangements in the developing animal forms

发育中动物形态中细胞重排的机械控制

• 发表时间: 2012
• 作者: Shizue Ohsawa;Kaoru Sugimura;Kyoko Takino;and Tatsushi Igaki.;S. Ishihara and K. Sugimura.;石原秀至;S. Ishihara and K. Sugimura.;石原秀至,杉村薫;石原秀至,杉村薫;石原秀至;石原秀至;S. Ishihara and K. Sugimura.;S. Ishihara and K. Sugimura.
• 通讯作者: S. Ishihara and K. Sugimura.

Bayesian inference of force dynamics during morphogenesis

• DOI: 10.1016/j.jtbi.2012.08.017
• 发表时间: 2012-11-21
• 期刊: JOURNAL OF THEORETICAL BIOLOGY
• 影响因子: 2
• 作者: Ishihara, Shuji;Sugimura, Kaoru
• 通讯作者: Sugimura, Kaoru