Development of the recognition molecule for 8-oxo-rG in RNA

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In this study, we developed the novel nucleoside analogues for the recognition of the damage to the nucleic acid in order to establish a new diagnosis of disease based on the stress. 8-Oxo-G is the oxidative damage base of guanine, and it is unknown the properties of it in single-stranded RNA. Thus, the purpose of the present work was developed a sequence specific detection molecules and methods of 8-oxo-rG in RNA. We developed a new synthesis method of RNA-type 8-oxoG. And we found the novel nucleoside analogues, 2-amino-Adap and 2'-OMe-Adap. These analogues could recognize and detect the 8-oxo-rG in RNA.