IgG4 reaction in cholangiocarcinoma and pancreatic carcinoma reflects an evasion from host immunosurveilance by carcinoma

胆管癌和胰腺癌中的 IgG4 反应反映了癌症逃避宿主免疫监视

• 批准号: 24659160
• 负责人: NAKANUMA YASUNI
• 金额: $ 2.41万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659160/
• 关键词: 付属腺; 胆道腫瘍; 膵腫瘍; 膵外分泌腺

The relation between cholangiocarcinoma and its precursor lesion (BilIN) and IgG4-related tissue reaction with respect to carcinogenesis was examined. About 30% of cholangiocarcinoma and BilIN showed infiltration of considerable number of IgG4+ plasma cells. There is correlation between expression of Fox3 and IgG4 tissue reaction. Clinicopathological study showed that the cholangiocarcinoma patients with IgG4 tissue reaction showed poor biological behaviors and poor post-operative survival. Cell culture studies showed that cultured cholangiocarcinoma cells express Fox3 mRNA and IL10 mRNA, and cancer cells present immunoregulatory roles by expressing these molecules. It seems plausible that cancer cells themselves are involved in IgG4 tissue reaction. In conclusion, some cholangiocarcinoma showed rich IgG4+ plasma cells and IgG4 tissue reaction reflect an evasion from immunosurveillance of host and cancer cells themsevels are involved in IgG4 tissue reaction by playing roles of Tregs.

胆管癌及其前病变（BilIN）和IgG 4相关的组织反应与癌变之间的关系进行了研究。约30%的胆管癌和BilIN显示了相当数量的IgG 4+浆细胞浸润。Fox3的表达与IgG 4的组织反应有相关性。临床病理学研究表明，胆管癌组织中IgG 4阳性者生物学行为差，术后生存率低。细胞培养研究表明，培养的胆管癌细胞表达Fox3 mRNA和IL 10 mRNA，并且癌细胞通过表达这些分子来呈现免疫调节作用。癌细胞本身参与IgG4组织反应似乎是合理的。结论：胆管癌组织中存在丰富的IgG 4+浆细胞，IgG 4组织反应反映了胆管癌细胞逃避宿主免疫监视，癌细胞自身通过发挥T淋巴细胞的作用参与IgG 4组织反应。

项目成果

IgG4関連疾患の肝病変. IgG4関連疾患に見られる末梢肝組織病変

IgG4 相关疾病中的肝脏病变 IgG4 相关疾病中可见的周围肝组织病变。

• 发表时间: 2013
• 作者: 原田憲一;中沼安二
• 通讯作者: 中沼安二

IgG4関連疾患の肝病変. IgG4関連疾患に見られる末梢肝組織病変.

IgG4 相关疾病中的肝脏病变 IgG4 相关疾病中可见的周围肝组织病变。

• 作者: 原田 憲一; 中沼 安二
• 通讯作者: 中沼 安二

Significance of IgG4-positive cells in extrahepatic cholangiocarcinoma: Molecular mechanism of IgG4 r5ection in cancer tissue

IgG4阳性细胞在肝外胆管癌中的意义：癌组织中IgG4表达的分子机制

• 发表时间: 2012
• 期刊: Hepatology
• 影响因子: 13.5
• 作者: Harada K;Shimoda S;Kimura Y;Sato Y;Ikeda H;Igarashi S;Ren XS;Sato H;Nakanuma Y.
• 通讯作者: Nakanuma Y.

IgG4関連膵胆道疾患の診断と治療. IgG4関連膵胆道疾患の病理

IgG4相关胰胆疾病的诊断和治疗 IgG4相关胰胆疾病的病理学。

• 发表时间: 2013
• 作者: Yamada K;Hamaguchi Y;Saeki T;Nakanuma Y;中沼安二.
• 通讯作者: 中沼安二.

自己免疫性膵炎合併の有無からみたIgG4硬化性胆管炎の病態の違い

根据是否存在自身免疫性胰腺炎，IgG4 硬化性胆管炎的病理学差异

• 发表时间: 2013
• 作者: 原田憲一;中沼安二
• 通讯作者: 中沼安二