New DC-mediated machinery to fine-tune excessive immune responses
New DC-mediated machinery to fine-tune excessive immune responses
批准号:
24659219
负责人:
OHTEKI Toshiaki
金额:
$2.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012 至 --
中文摘要
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英文摘要
Henophagocytpsis is conventionally viewed as an indicator of severe inflammation. We established a murine model for hemophagocytosis. Using this model, we newly found that DC-mediated hemophagocytosis is the machinery to fine-tune excessive immune responses and assure host survival under severe infectious and inflammatory conditions.
期刊论文(15)
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東京医科歯科大学難治疾患研究所生体防御学分野HP
东京医科齿科大学疑难杂症研究所生物防卫科 HP
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Monocyte-derived dendritic cells perform hemophagocytosis to control ecessive immune response.
单核细胞衍生的树突状细胞执行噬血作用来控制过度的免疫反应。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Onai N, Ohyagi H, Sato T, Yotsumoto S,Kurabayashi K, Hosoi-Amaike M, Sawada K, and Ohteki T, Ohteki T, 樗木俊聡, 樗木俊聡, 樗木俊聡, 小内伸幸]
通讯作者:
小内伸幸
Role for monocyte-derived cells in fine-tuning excessive immune responses.
单核细胞衍生细胞在微调过度免疫反应中的作用。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Onai N, Ohyagi H, Sato T, Yotsumoto S,Kurabayashi K, Hosoi-Amaike M, Sawada K, and Ohteki T, Ohteki T, 樗木俊聡, 樗木俊聡, 樗木俊聡]
通讯作者:
樗木俊聡
DOI:
10.1016/j.immuni.2013.06.019
发表时间:
2013-09-19
期刊:
IMMUNITY
影响因子:
32.4
作者:
[Ohyagi, Hideaki, Onai, Nobuyuki, Ohteki, Toshiaki]
通讯作者:
Ohteki, Toshiaki
Monocyte derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses during chronic virus infection.
单核细胞衍生的树突状细胞执行噬血作用,以微调慢性病毒感染期间的过度免疫反应。
DOI:
--
发表时间:
2022
期刊:
影响因子:
--
作者:
[Tchen John, Simon Quentin, Chapart L?a, Pellefigues Christophe, Karasuyama Hajime, Miyake Kensuke, Blank Ulrich, Benhamou Marc, Daugas Eric, Charles Nicolas, 竹馬 俊介, Nobuyuki Onai]
通讯作者:
Nobuyuki Onai
共 10 条
Identification of human DC and monocyte progenitors
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批准号:15K15150
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2015
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负责人:OHTEKI Toshiaki
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依托单位:
Comprehensive understanding of dendritic cell progenitor and its therapeutic application basis
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批准号:26253029
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$25.79万
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财政年份:2014
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负责人:OHTEKI Toshiaki
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依托单位:
Type-I IFN-dependent control of HSCs and its therapeutic applications for congenital and hematopoietic disorders
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批准号:21249033
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$13.64万
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财政年份:2009
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负责人:OHTEKI Toshiaki
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依托单位:
ACTIVATION MECHANISM OF INNATE IMMUNE SYSTEM BY INTERLEUKIN-15
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批准号:19390136
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.31万
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财政年份:2007
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负责人:OHTEKI Toshiaki
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依托单位:
Regulation of hematopoiesis by dendritic cells
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批准号:17590978
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:OHTEKI Toshiaki
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依托单位:
Regulatory mechanism of homeostatic T cell proliferation
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批准号:14599011
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2002
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负责人:OHTEKI Toshiaki
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依托单位:
海外基金