Identification of multi-level regulation of gene expression that determines B cell development

我们发现在B细胞向浆细胞分化的过程中，组蛋白变体的沉积显著减少。我们还通过chip-seq和mRNA-seq证实了组蛋白变体与分化过程中表达的基因的调控元件结合。此外，在B细胞中组成型表达his ton变体导致浆细胞生成的抑制。提示B细胞的分化受染色质结构动态变化的控制。

We found that the deposition of histone variant was markedly decreased during B cell differentiation into plasma cells. We also confirmed by chip-seq and mRNA-seq that the histone variant bind to the regulatory element of genes that will be expressed during differentiation. Furthermore, constitutive expression of his ton variant in B cells resulted in the inhibition of plasma cell generation. These findings suggest that B cel differentiation is controlled by dynamic change of chromatin structure.