Relationship between Early Exposure to Tobacco Smoke and Intima Media Thickness (IMT) in COPD patients

COPD 患者早期接触烟草烟雾与内膜中层厚度 (IMT) 的关系

• 批准号: 24659246
• 负责人: EBIHARA Akinori
• 金额: $ 1.25万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659246/
• 关键词: 早期喫煙暴露; 喫煙; COPD; IMT; vascular comorbidities; systemic effects; 禁煙; ＣＯＰＤ; ＩＭＴ; 心血管イベント; 合併症; 併存症; ｓystemic effects; 頸動脈内膜中膜複合体肥厚度; 動脈硬化; 脳血管障害

We hypothesized that COPD from early exposure to tobacco smoke may cause an increase of the intima media thickness (IMT) that correlates with the increase in the prevalence of smoke-related vascular comorbidities such as cardiovascular and cerebrovascular diseases. We divided potential subjects from the Erimo town clinic into three groups. A total of 152 subjects were enrolled into the study after informed consents were obtained. Groups with a history of COPD tended to have higher maximum values of IMT when compared with a group without COPD. Furthermore, Group 1 demonstrated highest value of IMT. In subjects with COPD, early smoke exposure promoted atherosclerotic changes, which may increase the likelihood of smoke-related vascular comorbidities such as cardiovascular and cerebrovascular diseases.

我们假设，早期接触烟草烟雾导致的慢性阻塞性肺病可能会导致内膜中层厚度（IMT）增加，这与吸烟相关血管合并症（如心脑血管疾病）患病率的增加相关。 我们将来自 Erimo 镇诊所的潜在受试者分为三组。获得知情同意后，共有 152 名受试者纳入研究。与没有 COPD 的组相比，有 COPD 病史的组往往具有更高的 IMT 最大值。此外，第 1 组表现出最高的 IMT 值。在患有慢性阻塞性肺病的受试者中，早期接触烟雾会促进动脉粥样硬化的变化，这可能会增加与烟雾相关的血管合并症（如心脑血管疾病）的可能性。

项目成果

Relationship between early exposure to tobacco smoke and intima media thickness (IMT) in COPD patients

COPD患者早期接触烟草烟雾与内膜中层厚度（IMT）的关系

• 发表时间: 2012
• 作者: 海老原明典;渡邉覚文;永井明日香;中野隆之;岩元徳全;桑平一郎;A.EBIHARA.
• 通讯作者: A.EBIHARA.

Relationship between the influence of exposure to tobacco smoke and max-IMT, ABI, ratio of EPA / AA in COPD patients

COPD患者烟草烟雾暴露与max-IMT、ABI、EPA/AA比值的关系

• 发表时间: 2013
• 作者: A.Ebihara;A.Watanabe;A.Nagai;T.Nakano;T.Iwamoto;I.Kuwahira.
• 通讯作者: I.Kuwahira.

The Influence of Early Exposure to Tobacco Smoke for Pulmonary Disease. - One town model from Erimo, Japan -

早期接触烟草烟雾对肺部疾病的影响。

• 发表时间: 2012
• 期刊: Health Evaluation and Promotion
• 作者: Akinori Ebihara;Asuka Nagai;Takayuki Nakano;Gen Sasao;Tokuzen Iwamoto;Ichiro Kuwahira.
• 通讯作者: Ichiro Kuwahira.

COPD患者における喫煙の影響とMax-IMT, ABI, EPA/AA 比の比較検討

吸烟对 COPD 患者 Max-IMT、ABI 和 EPA/AA 比值影响的比较研究

• 发表时间: 2013
• 作者: 海老原明典;渡邉覚文;永井明日香;中野隆之;岩元徳全;桑平一郎
• 通讯作者: 桑平一郎

Relationship between the influence of exposure to tobacco smoke and max-IMT, ABI, ratio of EPA/AA in COPD patients

COPD患者烟草烟雾暴露与max-IMT、ABI、EPA/AA比值的关系

• 发表时间: 2013
• 作者: Akinori Ebihara;Asuka Nagai;Takayuki Nakano;Gen Sasao;Tokuzen Iwamoto;Ichiro Kuwahira.;A.EBIHARA.;A.EBIHARA.
• 通讯作者: A.EBIHARA.