Development of a system with expanded PK-PD-PG theoretical model to prevent of adverse effects

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In the patients treated with tizanidine, approximately 45 % of the patients were co-administered with CYP1A2 inhibitors. Adverse effects induced co-administration of CYP1A2 inhibitors were observed in 23% of these patients. Tizanidine and cimetidine co-administration study was conducted in 6 healthy subjects. The prediction of adverse effects induced by tizanidine in the patients treated with tizanidine and cimetidine wereapplicable by using these data.