Development of a system with expanded PK-PD-PG theoretical model to prevent of adverse effects

开发具有扩展 PK-PD-PG 理论模型的系统，以防止不良影响

• 批准号: 24659256
• 负责人: KOHDA Yukinao
• 金额: $ 2.5万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659256/
• 关键词: 応用薬理学; 副作用; 薬物動態; 薬物相互作用; Cytochrome P450 1A2

In the patients treated with tizanidine, approximately 45 % of the patients were co-administered with CYP1A2 inhibitors. Adverse effects induced co-administration of CYP1A2 inhibitors were observed in 23% of these patients. Tizanidine and cimetidine co-administration study was conducted in 6 healthy subjects. The prediction of adverse effects induced by tizanidine in the patients treated with tizanidine and cimetidine wereapplicable by using these data.

在接受替扎尼定治疗的患者中，大约45%的患者与CYP1A2抑制剂联合使用。在这些患者中，有23%的患者观察到联合应用CYP1A2抑制剂引起的不良反应。在6名健康受试者中进行替扎尼定和西咪替丁联合给药研究。用这些数据可以预测替扎尼定和西咪替丁治疗患者中替扎尼定引起的不良反应。

项目成果

チザニジンの血中濃度に及ぼすシメチジン併用の影響

联合使用西咪替丁对替扎尼定血药浓度的影响

• 发表时间: 2012
• 作者: 百 賢二;本間真人;大坂佳子;猪股伸一;田中 誠;幸田幸直
• 通讯作者: 幸田幸直

Clinical Survey of Tizanidine-induced Adverse Effects -Impact of Concomitant Drugs Providing Cytochrome P450 1A2 Modification-

• DOI: 10.1248/yakushi.12-00222
• 发表时间: 2013-02-01
• 期刊: YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
• 影响因子: 0.3
• 作者: Momo, Kenji;Homma, Masato;Kohda, Yukinao
• 通讯作者: Kohda, Yukinao