Development of a system with expanded PK-PD-PG theoretical model to prevent of adverse effects

在接受替扎尼定治疗的患者中，约45%的患者同时接受CYP1A2抑制剂给药。在23%的这些患者中观察到CYP1A2抑制剂联合给药诱导的不良反应。在6名健康受试者中进行了替扎尼定和西咪替丁联合给药研究。这些数据可用于预测替扎尼定与西咪替丁联合用药的不良反应。

In the patients treated with tizanidine, approximately 45 % of the patients were co-administered with CYP1A2 inhibitors. Adverse effects induced co-administration of CYP1A2 inhibitors were observed in 23% of these patients. Tizanidine and cimetidine co-administration study was conducted in 6 healthy subjects. The prediction of adverse effects induced by tizanidine in the patients treated with tizanidine and cimetidine wereapplicable by using these data.