Establishment of the scoring system for predicting the prognosis of CKD patients.

预测CKD患者预后的评分系统的建立

• 批准号: 24659279
• 负责人: ABE Naoko
• 金额: $ 2.5万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659279/
• 关键词: CKD; 慢性腎臓病; 予後; バイオマーカー; 予後予測マーカー; podocyte; エクソゾーム

The worldwide rise in the number of patients with chronic kidney disease (CKD) and consequent end-stage renal failure is a global public health problem. Current screening strategies, based on creatinine or albuminuria, fail to identify a considerable number of subjects with CKD. We first isolate exosomes from various CKD patients. We then examined the expression of podocyte-derived exosomal transcriptional factors (PDETFs) in urine from various CKD patients with gross proteinuria. While extent of albuminuria was not different, progressing renal diseases such as diabetic nephropathy exhibited high levels of urinary PDETFs. Glomerular expression of PDETFs was decreased in accordance with the amount of PDETFs in urine of the patients. The higher amount of urinary PDETFs secreted, the earlier the renal function declined. Evaluation and analysis of PDETFs would provide some clues to understanding the molecular linkage between CKD and CVD.

慢性肾脏病（CKD）患者的数量在全球范围内不断增加，并随之出现终末期肾衰竭，这是一个全球性的公共卫生问题。目前的筛查策略，基于肌酐或白蛋白尿，未能确定相当数量的CKD受试者。我们首先从各种CKD患者中分离外泌体。然后，我们研究了足细胞衍生的外泌体转录因子（PDETFs）的表达在尿中的各种CKD患者与总蛋白尿。虽然白蛋白尿的程度没有差异，但进展性肾脏疾病（如糖尿病肾病）表现出高水平的尿PDETFs。肾小球PDETF的表达随着患者尿液中PDETF的含量而减少。尿PDETFs分泌量越高，肾功能下降越早。PDETFs的检测和分析将为进一步了解CKD和CVD之间的分子联系提供线索。

项目成果

Dual involvement of growth arrest-specific gene 6 in the early phase of human IgA nephropathy.

• DOI: 10.1371/journal.pone.0066759
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Nagai K;Miyoshi M;Kake T;Fukushima N;Matsuura M;Shibata E;Yamada S;Yoshikawa K;Kanayama HO;Fukawa T;Yamaguchi K;Izaki H;Mima A;Abe N;Araoka T;Murakami T;Kishi F;Kishi S;Tominaga T;Moriya T;Abe H;Doi T
• 通讯作者: Doi T

Multiple regulatory pathways of BMP-Smad axis through a sclerosis-specific basic HLH transcription factor in diabetic nephropathy

糖尿病肾病中 BMP-Smad 轴通过硬化特异性碱性 HLH 转录因子的多重调节途径

• 发表时间: 2013
• 作者: Yui Fujita;Akiko Sakurai;Tatsuya Tominaga;Sanae Hayashi;Naoko Abe;Toshio Doi;Hideharu Abe
• 通讯作者: Hideharu Abe

Predictive biomarkers for kidney function declines : podocyte-derived exosomal transcriptional factors

肾功能下降的预测生物标志物：足细胞衍生的外泌体转录因子

• 发表时间: 2012
• 作者: 安部尚子;林早苗;土井俊夫;安部秀斉
• 通讯作者: 安部秀斉

Predictive biomarkers for kidney function declines: podocyte-derived exosomal transcriptional factors

肾功能下降的预测生物标志物：足细胞衍生的外泌体转录因子

• 发表时间: 2012
• 作者: 安部尚子;他
• 通讯作者: 他

Scleraxis modulates bone morphogenetic protein 4 (BMP4)-Smad1-smooth muscleαactin (SMA) signal transduction in diabetic nephropathy

Scleraxis 调节糖尿病肾病中骨形态发生蛋白 4 (BMP4)-Smad1-平滑肌 α 肌动蛋白 (SMA) 信号转导

• 发表时间: 2012
• 期刊: J Biol Chem
• 影响因子: 4.8
• 作者: Abe H;Tominaga T;Matsubara T;Abe N;Kishi S;Nagai K;Murakami T;Araoka T;Doi T.
• 通讯作者: Doi T.