Trends in Intraparenchymal Hemorrhage Subtypes and Its Risk Factors.

实质内出血亚型的趋势及其危险因素。

• 批准号: 24659321
• 负责人: OHIRA Tetsuya
• 金额: $ 2.5万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659321/
• 关键词: 疫学; 脳出血; 推移; 前向き研究; 危険因子; 脳内出血; トレンド; 病型; 高血圧; 低コレステロール; 飲酒

The incidence of intraparenchymal hemorrhage (IPH) from 1986 to 2010 was ascertained by systematic surveillance in three Japanese Communities. The incidence of deep IPH has tended to have increased from 1986 to 2010, while the incidence of lobar and cerebellar IPH has been flat.A prospective study of Japanese subjects aged 40-69 years was undertaken using data collected from 9,086 participants in cardiovascular risk surveys conducted in three communities between 1985 and 1994. The incidence of IPH between 1985 and 2010 was ascertained by systematic surveillance. During an average follow up of 20.5-years, 144 incident IPHs occurred. Systolic blood pressure, body mass index, major ST-T abnormality on electrocardiogram, and excess ethanol intake (>=46g/day) were associated with increased risk of deep ICH, while serum total cholesterol levels were inversely associated with incidence of lobar and cerebellar IPH, even after adjustment for potential confounding variables.

通过对日本三个社区的系统监测，确定了1986年至2010年间实质内出血(IPH)的发病率。从1986年到2010年，深部IPH的发病率呈上升趋势，而大脑叶和小脑IPH的发病率一直持平。一项针对40-69岁日本受试者的前瞻性研究使用了1985至1994年间在三个社区进行的9,086名心血管风险调查参与者的数据。通过系统监测，确定1985年至2010年间的IPH发病率。在平均20.5年的随访期内，共发生144例IPHS事件。收缩压、体重指数、心电图上的主要ST-T异常和过量酒精摄入(&gt；=46g/天)与深部脑出血的风险增加相关，而血清总胆固醇水平与脑叶和小脑IPH的发生率呈负相关，即使在调整了潜在的混杂变量后也是如此。

项目成果

脳出血の部位別にみた危険因子の検討: the Circulatory Risk in Communities Study (CIRCS)

按部位检查脑出血危险因素：社区循环风险研究 (CIRCS)

• 发表时间: 2014
• 作者: 大平哲也;今野弘規;江口依里;北村明彦;木山昌彦;山岸良匡;山海知子;崔仁哲;岡田武夫;梅澤光政;谷川武;磯博康;大平哲也
• 通讯作者: 大平哲也

CIRCS Investigators. High-density lipoprotein subclasses and risk of stroke and its subtypes in Japanese population : the Circulatory Risk in Communities Study

CIRCS 调查员。

• 发表时间: 2013
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Chei CL;Yamagishi K;Kitamura A;Kiyama M;Imano H;Ohira T;Cui R;Tanigawa T;Sankai T;Ishikawa Y;Sato S;Hitsumoto S;Iso H.
• 通讯作者: Iso H.

Heavy alcohol consumption and risk of atrial fibrillation : Circulatory Risk in Communities Study (CIRCS).

大量饮酒和心房颤动的风险：社区循环风险研究 (CIRCS)。

• 发表时间: 2014
• 期刊: Circ J
• 影响因子: 3.3
• 作者: Sano F;Ohira T;Kitamura A;Imano H;Cui R;Kiyama M;Okada T;Yamagishi K;Sankai T;Tanigawa T;Kario K;Iso H.
• 通讯作者: Iso H.

Trends in hemorrhagic stroke in Japan, from 1986 to 2010: the Circulatory Risk in Communities Study (CIRCS).

1986 年至 2010 年日本出血性中风的趋势：社区循环风险研究 (CIRCS)。

• 发表时间: 2013
• 作者: Eguchi E;Ohira T;Imano H;Kitamura A;Kiyama M;Okada T;Yamagishi K;Sankai T;Umesawa M;Cui R;Maruyama M;Tanigawa T;Ishikawa Y;Iso H.;Ohira T;Eguchi E
• 通讯作者: Eguchi E

Adult height and body mass index in relation to risk of total stroke and its subtypes : the Circulatory Risk in Communities Study (CIRCS)

成人身高和体重指数与总中风及其亚型风险的关系：社区循环风险研究 (CIRCS)

• 发表时间: 2014
• 期刊: J Stroke Cerebrovasc Dis
• 作者: Shimizu Y;Imano H;Ohira T;Kitamura A;Kiyama M;Okada T;Ishikawa Y;Shimamoto T;Yamagishi K;Tanigawa T;Iso H.
• 通讯作者: Iso H.