Molecular identity and mechanisms of lipolysis-stimulated insulin secretion

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This study was aimed at elucidating the molecular mechanisms of catecholamine-induced insulin secretion. We have previously identified a profound defect of this phenomenon in mice with a targeted disruption of HSL, which is one of the major lipases involved in adipocyte lipolysis. As the plasma levels of hormones that affect insulin secretion were similar between wild-type and HSLKO mice, we reasoned some lipolytic products of HSL in adipocytes stimulate insulin secretion from beta cells in pancreas. Through metabolomics approach, we have identified several candidates, which have been further tested for the ability to stimulate insulin secretion.