Dual Stem Cell Therapy with Pharmacologically-Stimulated Mesenchymal Stem Cells

本研究探讨了间充质干细胞的潜力，通过药理学试剂刺激的应用于造血干细胞移植。甲状旁腺激素可提高致死剂量照射小鼠骨髓移植的存活率，并刺激间充质干细胞促进造血细胞的扩增。间充质干细胞可以从体积小的脐带血单位中分离出来，这对于脐带血移植是不可用的。分离的脐血间充质干细胞具有与骨髓间充质干细胞相当的增殖和多向分化能力。

This study has examined potential of mesenchymal stem cells that are stimulated by pharmacological agents for the application to hematopoietic stem cell transplantation. Parathyroid hormone improved the survival of lethally-irradiated mice in bone marrow transplantation and stimulated mesenchymal stem cells to enhance the expansion of hematopoietic cells. Mesenchymal stem cells can be isolated from an umbilical cord blood unit with small volume that is unavailable for umbilical cord blood transplantation. The isolated umbilical cord blood mesenchymal stem cells showed the proliferation and multi-differentiation capabilities that are equivalent to bone marrow mesenchymal stem cells.