Tumor specific delivery of nucleic acid using patient's dendritic cell-derived exosome
Tumor specific delivery of nucleic acid using patient's dendritic cell-derived exosome
批准号:
24659500
负责人:
HOSOI Hajime
金额:
$2.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
Innovative therapeutics is required to improve prognosis of pediatric cancer. Several tumor suppressor microRNAs are identified and clinical application of microRNAs are suggested. Exosome plays important roles in intercellular communication of microRNA. We examined if exosome can be used to deliver tumor suppressor microRNA to pediatric cancer cells. It is revealed that pediatric cancer cells secrete exosome, that expression pattern of exosome-derived microRNA is similar to that of cellular microRNA and that exosome functions as menas of intercellular communication. Our findings suggested that exosome can be used as means of microRNA delivery.
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High serum miR-206 expression levels define an aggressive rhabdomyosarcoma subtype
高血清 miR-206 表达水平定义了侵袭性横纹肌肉瘤亚型
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Yamanaka, Y., 新垣理恵子, Hosoi H]
通讯作者:
Hosoi H
DOI:
10.1002/gcc.22170
发表时间:
2014-07-01
期刊:
GENES CHROMOSOMES & CANCER
影响因子:
3.7
作者:
[Yoshida, Hideki, Miyachi, Mitsuru, Hosoi, Hajime]
通讯作者:
Hosoi, Hajime
血清miR-206は、転移性横紋筋肉腫において高発現を示す
血清 miR-206 在转移性横纹肌肉瘤中高表达
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[宮地 充, 土屋邦彦, 細井 創, 他]
通讯作者:
他
胞巣型横紋筋肉腫において、血清 miR-206 は高発現を示す
血清miR-206在肺泡型横纹肌肉瘤中高表达
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[下倉良太, 高木悠哉, 西村忠己, 細井裕司, 東 範行, 大芦孝平,古川洋志,大澤昌之,山本有平, 宮地 充,土屋邦彦,柳生茂希,今村俊彦,家原知子,細井 創]
通讯作者:
宮地 充,土屋邦彦,柳生茂希,今村俊彦,家原知子,細井 創
血清miR-206 は,転移性横紋筋肉腫において高発現を示す
血清miR-206在转移性横纹肌肉瘤中高表达
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Bengua G, Ishikawa M, Sutherl, K, Horita K, Yamazaki R, Fujita K, Onimaru R, Katoh N, Inoue T, Onodera S, Shirato H., 植田直見(代表)・伊藤健司・金益柱・姜大一ほか1名 計5名, 石丸直澄, 細井創]
通讯作者:
細井創
共 11 条
The development of novel diagnostics and treatment for refractory rhabdomyosarcoma
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批准号:22390329
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.57万
-
财政年份:2010
-
负责人:HOSOI Hajime
-
依托单位:
EVALUATION OF PROGNOSIS AND EFFICACY OF THERAPY FOR NEUROBLASTOMA PATIENTS BY QUANTIFICATION OF METHYLATED DCR2 GENE PROMOTER IN SERUM DNA
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批准号:18390300
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.77万
-
财政年份:2006
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负责人:HOSOI Hajime
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依托单位:
STUDY OF SIGNALTRANSDUCTION PATHWAY FOR TERMINAL DIFFERENTIATION OF RHABDOMYOSARCOMA CELLS
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批准号:11470174
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$4.22万
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财政年份:1999
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负责人:HOSOI Hajime
-
依托单位:
Tumor-biological significance of Myc-relarted gene products in neuroblastoma cells
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批准号:10670749
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:1998
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负责人:HOSOI Hajime
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依托单位:
海外基金