Harnessing tissue homeostasis-promoting functions of specialized regulatory T cells in graft-versus-host disease (B08)

利用专门调节性 T 细胞在移植物抗宿主病中促进组织稳态的功能 (B08)

• 批准号: 396497897
• 金额: --
• 依托单位: Leibniz-Institut für Immuntherapie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/396497897?language=en
• 关键词: Harnessing; tissue; homeostasis; promoting; functions

Regulatory T cells (Treg) perform two distinct functions: they maintain self-tolerance and support tissue-repair and organ homeostasis by differentiation into specialized tissue Treg cells. We aim to harness the tissue-repair function of tissue-Treg cells to prevent or treat graft-versus-host disease after allogeneic bone marrow transplantation. In this respect, we want to identify tissue-repair factors and will engineer and study ‘tissue smart’ Treg cells for the therapy of GvHD. We will translate these findings to human Treg cells to establish novel Treg cell therapy formats.

调节性T细胞（Treg）执行两种不同的功能：它们通过分化成专门的组织Treg细胞来维持自身耐受性并支持组织修复和器官稳态。我们的目标是利用组织调节性T细胞的组织修复功能来预防或治疗异基因骨髓移植后的移植物抗宿主病。在这方面，我们希望识别组织修复因子，并将设计和研究用于治疗GvHD的“组织智能”Treg细胞。我们将把这些发现转化为人类Treg细胞，以建立新型Treg细胞治疗模式。