Harnessing tissue homeostasis-promoting functions of specialized regulatory T cells in graft-versus-host disease (B08)

点击翻译按钮获取中文摘要

Regulatory T cells (Treg) perform two distinct functions: they maintain self-tolerance and support tissue-repair and organ homeostasis by differentiation into specialized tissue Treg cells. We aim to harness the tissue-repair function of tissue-Treg cells to prevent or treat graft-versus-host disease after allogeneic bone marrow transplantation. In this respect, we want to identify tissue-repair factors and will engineer and study ‘tissue smart’ Treg cells for the therapy of GvHD. We will translate these findings to human Treg cells to establish novel Treg cell therapy formats.