Mechanism of atherosclerosis progression by platelet-derived inflammatory cytokines in carotid artery stenosis

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This study revealed that shear-induced platelet-derived inflammatory cytokines, such as sCD40L, interleukins, increase in time-dependent manner. In carotid stenosis patients, a significant time-dependent increase of platelet-derived inflammatory cytokines was observed in the patients with diabetes compared to the patient without it. The clinical study for the patients with carotid artery stenosis to elucidate the correlation between cardiovascular events, plaque volume, and lipid ratio and inflammatory cytokines value revealed that the value of inflammatory cytokines are significantly high in the patients developed cerebrovascular event and the patients with vulnerable plaque. About its mechanism and its intracellular signal transduction are still under consideration. Some of these content has been already reported in journals(J Stroke Cerebrovasc Dis. 2012).