Mechanism of atherosclerosis progression by platelet-derived inflammatory cytokines in carotid artery stenosis

颈动脉狭窄中血小板源性炎症细胞因子导致动脉粥样硬化进展的机制

• 批准号: 24659646
• 负责人: IWAMA Toru
• 金额: $ 2.33万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659646/
• 关键词: 主幹動脈狭窄症; 炎症性サイトカイン; 動脈硬化進展作用; 主幹動脈狭窄症炎症

This study revealed that shear-induced platelet-derived inflammatory cytokines, such as sCD40L, interleukins, increase in time-dependent manner. In carotid stenosis patients, a significant time-dependent increase of platelet-derived inflammatory cytokines was observed in the patients with diabetes compared to the patient without it. The clinical study for the patients with carotid artery stenosis to elucidate the correlation between cardiovascular events, plaque volume, and lipid ratio and inflammatory cytokines value revealed that the value of inflammatory cytokines are significantly high in the patients developed cerebrovascular event and the patients with vulnerable plaque. About its mechanism and its intracellular signal transduction are still under consideration. Some of these content has been already reported in journals(J Stroke Cerebrovasc Dis. 2012).

本研究揭示了剪切诱导的血小板源性炎性细胞因子，如sCD 40 L，白细胞介素，以时间依赖性的方式增加。在颈动脉狭窄患者中，与无糖尿病的患者相比，糖尿病患者血小板源性炎症细胞因子呈时间依赖性显着增加。针对颈动脉狭窄患者的临床研究旨在阐明心血管事件、斑块体积、血脂比值和炎性细胞因子值显示，发生脑血管事件的患者炎性细胞因子值显著升高和易损斑块患者。其作用机制和细胞内信号转导机制尚在研究中。其中一些内容已经在期刊上报道过（J Stroke Cerebrovasc Dis. 2012）。

项目成果

Correlation between light transmission aggregometry and VerifyNow assay in the patients undergoing neuroendovascular therapy.

接受神经血管内治疗的患者的光透射聚集测量与VerifyNow测定之间的相关性。

• 发表时间: 2012
• 作者: 榎本由貴子;吉村紳一;江頭裕介;石黒光紀;宮居雅文;澤田重信;岩間 亨;戸田 満秋 他;旭 雄士;Enomoto Y
• 通讯作者: Enomoto Y

岐阜大学医学部脳神経外科

岐阜大学医学院神经外科

The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment.

• DOI: 10.1186/1742-2094-10-105
• 发表时间: 2013-08-23
• 期刊: Journal of neuroinflammation
• 影响因子: 9.3
• 作者: Egashira Y;Suzuki Y;Azuma Y;Takagi T;Mishiro K;Sugitani S;Tsuruma K;Shimazawa M;Yoshimura S;Kashimata M;Iwama T;Hara H
• 通讯作者: Hara H

Silent Coronary Artery Disease in Japanese Patients Undergoing Carotid Artery Stenting

• DOI: 10.1016/j.jstrokecerebrovasdis.2012.12.013
• 发表时间: 2013-10-01
• 期刊: JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
• 影响因子: 2.5
• 作者: Enomoto, Yukiko;Yoshimura, Shinichi;Iwama, Toru
• 通讯作者: Iwama, Toru

Long-term magnetic resonance angiography follow-up of recanalized vessels after mechanical clot extraction

机械血栓提取后血管再通的长期磁共振血管造影随访

• 发表时间: 2013
• 作者: 藤村幹;清水宏明;井上敬;新妻邦泰;冨永悌二;榎本由貴子;Enomoto Y,Yoshimura S,Egashira Y,Iwama T
• 通讯作者: Enomoto Y,Yoshimura S,Egashira Y,Iwama T