Elucidation of biological functions of CD133, a marker for brain tumor-initiating cells, and its application
Elucidation of biological functions of CD133, a marker for brain tumor-initiating cells, and its application
批准号:
24659659
负责人:
IZAWA Ichiro
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
CD133 is utilized as a marker for tumor-initiating cells of glioma, but its physiological function is still not well understood. To dissect the function of CD133, we tried to identify CD133-binding proteins, using pull-down methods, immunoprecipitation assays, and yeast two-hybrid techniques. On the other hand, we found that in human embryonic carcinoma NTERA-2 cells, CD133 suppresses the expression of Epithelial Splicing Regulatory Protein 1 (ESRP1), an RNA splicing factor that regulates epithelial-mesenchymal transition (EMT).
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DOI:
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发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
細胞極性制御因子ScribbleはMRP4/ABCC4と相互作用する
细胞极性调节剂 Scribble 与 MRP4/ABCC4 相互作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Izawa, I, 井澤一郎]
通讯作者:
井澤一郎
DOI:
10.1074/jbc.m113.514737
发表时间:
2013-12-13
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
[Matsuyama M, Tanaka H, Inoko A, Goto H, Yonemura S, Kobori K, Hayashi Y, Kondo E, Itohara S, Izawa I, Inagaki M]
通讯作者:
Inagaki M
Interaction of Cell Polarity Regulator Scribble with Multidrug Resistance Protein 4 (MRP4/ABCC4)
细胞极性调节器 Scribble 与多药耐药蛋白 4 (MRP4/ABCC4) 的相互作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Izawa, I]
通讯作者:
I
LAP family protein Scribble interacts with Multidrug Resistance Protein 4 (MRP4/ABCC4)
LAP 家族蛋白 Scribble 与多药耐药蛋白 4 (MRP4/ABCC4) 相互作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Izawa, I]
通讯作者:
I
共 6 条
Development of peptide inhibitors targeting ADAM10 to eradicate brain tumor-initiating cells
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批准号:26670650
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2014
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负责人:IZAWA Ichiro
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依托单位:
Analysis of abnormal cell polarity in brain tumor cells
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批准号:21591887
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2009
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负责人:IZAWA Ichiro
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依托单位:
Elucidation of the link between the control of cell-cell adhesion by regulations of cell polarity and cell proliferation and differentitation
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批准号:18570142
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.63万
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财政年份:2006
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负责人:IZAWA Ichiro
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依托单位:
Dissection of roles of Densin-180, a cell polarity molecule, in synapses
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批准号:16500257
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2004
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负责人:IZAWA Ichiro
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依托单位:
Analysis of the regulation of intermediate filaments and desmosomes.
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批准号:14580662
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2002
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负责人:IZAWA Ichiro
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依托单位:
Analysis of the regulation of simple epithelia-specific intermediate filament proteins, Keratin 8/18
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批准号:12680645
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:2000
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负责人:IZAWA Ichiro
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依托单位:
海外基金