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Elucidation of biological functions of CD133, a marker for brain tumor-initiating cells, and its application

Elucidation of biological functions of CD133, a marker for brain tumor-initiating cells, and its application
脑肿瘤起始细胞标志物CD133的生物学功能及其应用的阐明
批准号:
24659659
负责人:
IZAWA Ichiro
金额:
$2.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

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中文摘要
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英文摘要
CD133 is utilized as a marker for tumor-initiating cells of glioma, but its physiological function is still not well understood. To dissect the function of CD133, we tried to identify CD133-binding proteins, using pull-down methods, immunoprecipitation assays, and yeast two-hybrid techniques. On the other hand, we found that in human embryonic carcinoma NTERA-2 cells, CD133 suppresses the expression of Epithelial Splicing Regulatory Protein 1 (ESRP1), an RNA splicing factor that regulates epithelial-mesenchymal transition (EMT).
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DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
細胞極性制御因子ScribbleはMRP4/ABCC4と相互作用する
细胞极性调节剂 Scribble 与 MRP4/ABCC4 相互作用
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Izawa, I, 井澤一郎]
通讯作者: 井澤一郎
DOI: 10.1074/jbc.m113.514737
发表时间: 2013-12-13
期刊: The Journal of biological chemistry
影响因子: --
作者: [Matsuyama M, Tanaka H, Inoko A, Goto H, Yonemura S, Kobori K, Hayashi Y, Kondo E, Itohara S, Izawa I, Inagaki M]
通讯作者: Inagaki M
Interaction of Cell Polarity Regulator Scribble with Multidrug Resistance Protein 4 (MRP4/ABCC4)
细胞极性调节器 Scribble 与多药耐药蛋白 4 (MRP4/ABCC4) 的相互作用
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Izawa, I]
通讯作者: I
6
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      26670650
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    • 资助金额:
      $2.33万
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      2014
    • 负责人:
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      Grant-in-Aid for Scientific Research (C)
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      $2.63万
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