Establishment and functional analysis of induced pluripotent cancer cells in ovarian cancer

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Honeycomb films (3D porous scaffold) exert an influence on cell adhesion and proliferation. Honeycomb films inhibited cell proliferation compared with control flat films in ovarian cancer cells, suggesting that honeycomb films have the possibility of inducing cancer cell to cancer stem cell and suppressing peritoneal spread of ovarian cancer. Ovarian cancer ascites were collected from patients who underwent surgery and we identified that primary CD11b+CD14+ cells, which were predominantly macrophages, are the major source of IL-6 production in an ovarian tumor microenvironment. When CD11b+CD14+ cells were co-cultured with cancer cells, the invasion and the proliferation of cancer cells were robustly promoted and these promotions were almost inhibited by the pretreatment of anti-IL-6R antibody (tocilizumab).