Role of the aryl hydrocarbon receptor in hepatic immune regulation (P03*)

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The aryl hydrocarbon receptor (AhR) is an important immune modulator that can integrate signals from environmental, microbial or metabolic ligands into the immune response. We will explore the role of AhR in the regulation of hepatic immune tolerance and inflammation, both at the level of T cells and hepatic antigen presenting cells. Furthermore, we will evaluate the therapeutic potential of AhR ligands for the treatment of inflammatory liver diseases.