From apoptotic cell sensing to an innate memory response: a new aspect of Kupffer cell function (P02*)

从凋亡细胞感知到先天记忆反应：库普弗细胞功能的新方面 (P02*)

• 批准号: 396771936
• 金额: --
• 依托单位: I. Medizinische Klinik und Poliklinik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/396771936?language=en
• 关键词: apoptotic; cell; sensing; innate; memory

Schistosomiasis is an acute and chronic disease caused by infection with the parasite Schistosoma. Upon infection, phagocytic macrophages in the liver, named Kupffer cells (KCs), acquire an anti-inflammatory phenotype which is essential for the initial tissue remodelling. However, at the later stage of infection, an exacerbated KC response is associated with fibrosis development. Here we will investigate whether, by sensing apoptotic cells, KCs can acquire an innate memory capacity, which not only improve tissue healing and fibrotic response, but also confer protection upon second challenge with the parasite.

血吸虫病是一种由寄生虫血吸虫感染引起的急慢性疾病。在感染后，肝脏中的吞噬巨噬细胞，称为库普弗细胞(KCs)，获得一种抗炎表型，这是最初的组织重建所必需的。然而，在感染的后期，KC反应的加剧与纤维化的发展有关。在这里，我们将研究KCs是否可以通过检测凋亡细胞获得天生的记忆能力，这不仅可以改善组织愈合和纤维化反应，还可以在第二次攻击寄生虫时提供保护。