High-resolution MR flow imaging for the characterization of arterial haemodynamics as an indicator of cellular pathomechanisms in early atherogenesis

高分辨率 MR 血流成像用于表征动脉血流动力学，作为早期动脉粥样硬化形成细胞病理机制的指标

• 批准号: 396923792
• 负责人: Professor Wolfgang Rudolf Bauer
• 金额: --
• 依托单位: Medizinische Klinik und Poliklinik I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/396923792?language=en
• 关键词: resolution; MR; flow; imaging; characterization

The non-invasive assessment of the pathomechanisms of atherosclerosis is an important tool for the development of new therapeutic and diagnostic procedures to improve the treatment and prevention of cardiovascular diseases. In particular, high-resolution MR imaging is a predominant technique for the investigation of morphological and functional parameters of the cardiovascular system. Since changes in the vascular function may represent precursors of structural remodeling, they are particularly suitable as an early diagnostic marker. As MR imaging in the mouse model, however, imposes high requirements on the spatial and temporal resolution, highly efficient imaging techniques are necessary. In recent years important advances could be achieved in functional MR imaging of the vessel wall, vascular mechanics and the visualization of local inflammation, by us and others. To enable high-resolution detection of local vessel wall parameters over the entire area of the aorta, existing imaging methods have to be accelerated and optimized.The goal of the proposed project is the development of new techniques for the assessment and characterization of the vessel wall in early stages of atherosclerosis, based on high resolution MR measurement techniques. A particular focus will be the study of local changes of mechanical parameters such as pulse wave velocity, wall shear stress and vascular impedance. In vitro arterial models provide a controlled environment of physiological and pathological conditions and thus are particularly suitable for the development and validation of new examination methods. Different flow dynamics are to be realized and characterized by means of highly resolved MRT, and their effects on the vessel physiology are to be examined down to a molecular biology level. Moreover, the extension of the arterial model to an atherosclerosis model is intended to provide information on the reaction of biological factors on the vessel hemodynamics.In the further course, functional imaging will be combined with the molecular and high-resolution morphological MR imaging in order to examine different influences on the development of atherosclerosis. Early diagnostic markers will subsequently be used to assess physiological processes of atherogenesis in longitudinal studies in atherosclerosis mouse models. Knowledge of the pathogenic mechanisms in the early stages of atherosclerosis is expected to serve as a basis for the development of therapeutic and prophylactic measures.

动脉粥样硬化病理机制的无创评估是开发新的治疗和诊断方法以改善心血管疾病的治疗和预防的重要工具。特别是，高分辨率磁共振成像是心血管系统形态学和功能参数研究的主要技术。由于血管功能的改变可能是结构重塑的前兆，因此它们特别适合作为早期诊断标志。然而，由于磁共振成像对小鼠模型的空间和时间分辨率要求很高，因此需要高效的成像技术。近年来，我们和其他人在血管壁的功能性磁共振成像、血管力学和局部炎症的可视化方面取得了重要进展。为了能够对整个主动脉区域的局部血管壁参数进行高分辨率检测，现有的成像方法必须得到加速和优化。该项目的目标是开发基于高分辨率MR测量技术的动脉粥样硬化早期血管壁评估和表征新技术。一个特别的重点将是局部变化的机械参数，如脉冲波速度，壁剪切应力和血管阻抗的研究。体外动脉模型提供了生理和病理条件的受控环境，因此特别适合于开发和验证新的检查方法。不同的流动动力学将通过高分辨率的MRT来实现和表征，它们对血管生理学的影响将被检查到分子生物学水平。此外，将动脉模型扩展到动脉粥样硬化模型旨在提供有关生物因素对血管血流动力学反应的信息。在接下来的课程中，功能成像将与分子和高分辨率形态磁共振成像相结合，以研究不同因素对动脉粥样硬化发展的影响。在动脉粥样硬化小鼠模型的纵向研究中，早期诊断标志物将随后用于评估动脉粥样硬化发生的生理过程。对动脉粥样硬化早期发病机制的了解有望成为制定治疗和预防措施的基础。