Natural Vibration Analysis of membrane protein and applicability to micro-sensor

对分布在细胞表面的一种蛋白质进行了自振分析，该蛋白质作为传感器获取自身周围的信息。蛋白质感知机械应力，转化为生化信号并对周围环境做出反应。本研究的目的是利用有限元法分析集成素的动态特性。整合素是细胞膜上的一种蛋白质，具有细胞粘附功能。三维结构由集中质量-弹簧系统建模，每个原子的坐标由开放的蛋白质数据库确定。利用NASTRAN软件的特征值分析计算了积分素的固有频率和正态模态。结果表明，整合素具有从几kHz到太赫兹的宽固有频率范围，以及相应的固有模式，这表明一种蛋白质可以感知宽频率的振动。

Natural vibration analysis was conducted for a protein distributed on the surface of a cell as a sensor to get information around itself. The proteins sense mechanical stress, translate to the biochemical signal and response to the surrounding environment. The purpose of this research is to analyze dynamic characteristics of integrin by using FEM. Integrin is a kind of protein on the cell membrane, and has function as cell adhesion.The three-dimensional structure was modeled by a concentrated mass-spring system, and coordinates of each atoms were determined by protein database open to the public. The natural frequency and normal mode of integrin was calculated by the eigenvalue analysis in NASTRAN. The result showed that integrin had a wide range of natural frequency from several kHz to THz, and the corresponding natural modes, which revealed that one protein might sense wide range of frequency of vibration.