Natural Vibration Analysis of membrane protein and applicability to micro-sensor

对分布在细胞表面的蛋白质作为传感器以获取其周围的信息进行了固有振动分析。这些蛋白质感知机械应力，转化为生化信号并对周围环境做出反应。本研究的目的是利用有限单元法分析整合素的动态特性。整合素是细胞膜上的一种蛋白质，具有细胞粘附的功能，其三维结构采用集中质量弹簧系统建模，各原子的坐标由公开的蛋白质数据库确定。利用NASTRAN中的特征值分析法计算了整联蛋白的固有频率和振型。结果表明，整合素具有从几kHz到THz的较宽的固有频率范围和相应的固有振动模式，揭示了一种蛋白质可以感知较宽的振动频率范围。

Natural vibration analysis was conducted for a protein distributed on the surface of a cell as a sensor to get information around itself. The proteins sense mechanical stress, translate to the biochemical signal and response to the surrounding environment. The purpose of this research is to analyze dynamic characteristics of integrin by using FEM. Integrin is a kind of protein on the cell membrane, and has function as cell adhesion.The three-dimensional structure was modeled by a concentrated mass-spring system, and coordinates of each atoms were determined by protein database open to the public. The natural frequency and normal mode of integrin was calculated by the eigenvalue analysis in NASTRAN. The result showed that integrin had a wide range of natural frequency from several kHz to THz, and the corresponding natural modes, which revealed that one protein might sense wide range of frequency of vibration.