Control of T cell motility by the biophysical properties of the tumor stroma (C10*)

通过肿瘤基质的生物物理特性控制 T 细胞运动 (C10*)

• 批准号: 397752773
• 金额: --
• 依托单位: Zentrum für Biologische Signalstudien (BIOOS)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/397752773?language=en
• 关键词: Control; cell; motility; biophysical; properties

This project will study the impact of tumor-associated fibroblasts on ECM remodeling and its influence on T cell infiltration. Breast, gastrointestinal and cutaneous squamous cell cancers will be used as working models. Physical proximity between T cells and cancer cells is required for T cell-mediated killing. Therefore, to understand the biophysical properties of the ECM and its influence on T cell migration and infiltration ability in the tumor microenvironment towards the tumor cells will be the ultimately goal to optimize T cell-based therapies.

本项目将研究肿瘤相关成纤维细胞对ECM重塑的影响及其对T细胞浸润的影响。乳腺癌、胃肠癌和皮肤鳞状细胞癌将被用作工作模型。T细胞介导的杀伤需要T细胞和癌细胞之间的物理接近。因此，了解细胞外基质的生物物理特性及其对T细胞在肿瘤微环境中向肿瘤细胞的迁移和渗透能力的影响将是优化T细胞治疗的最终目标。