Control of T cell motility by the biophysical properties of the tumor stroma (C10*)

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This project will study the impact of tumor-associated fibroblasts on ECM remodeling and its influence on T cell infiltration. Breast, gastrointestinal and cutaneous squamous cell cancers will be used as working models. Physical proximity between T cells and cancer cells is required for T cell-mediated killing. Therefore, to understand the biophysical properties of the ECM and its influence on T cell migration and infiltration ability in the tumor microenvironment towards the tumor cells will be the ultimately goal to optimize T cell-based therapies.