Hyaluronic acid-based bioink platform with multi-functional crosslinkers for the controlled differentiation of mesenchymal stem cells (A02)

透明质酸(HA)是人体细胞外基质的主要成分，但目前尚缺乏通用性强的HA基生物材料。该项目的总体目标是开发一种基于HA的生物墨水平台，利用多功能交联剂(聚乙二醇改性生物聚合物)实现骨髓间充质干细胞的可控分化。多肽和生长因子的修饰以及梯度材料的加工将进一步促进打印的3D结构中连贯组织的发展。从长远来看，这项工作的目的是为临床相关组织模型的开发生成生物墨水。

Hyaluronic acid (HA) represents a major component of the human extracellular matrix, however, so far highly versatile HA-based materials for biofabrication are lacking. The overall aim of this project is to develop a HA-based bioink platform utilizing multi-functional crosslinkers (PEG, modified biopolymers) that enables the controlled differentiation of mesenchymal stem cells. The modification with peptides and growth factors as well as the processing into gradient materials will further promote the development of coherent tissues within the printed 3D constructs. For the long term, this work aims to generate bioinks for the development of clinically relevant tissue models.