Hyaluronic acid-based bioink platform with multi-functional crosslinkers for the controlled differentiation of mesenchymal stem cells (A02)

基于透明质酸的生物墨水平台，具有多功能交联剂，用于间充质干细胞的受控分化（A02）

• 批准号: 397978556
• 金额: --
• 依托单位: Lehrstuhl für Funktionswerkstoffe der Medizin und der Zahnheilkunde
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/397978556?language=en
• 关键词: Hyaluronic; acid; based; bioink; platform

Hyaluronic acid (HA) represents a major component of the human extracellular matrix, however, so far highly versatile HA-based materials for biofabrication are lacking. The overall aim of this project is to develop a HA-based bioink platform utilizing multi-functional crosslinkers (PEG, modified biopolymers) that enables the controlled differentiation of mesenchymal stem cells. The modification with peptides and growth factors as well as the processing into gradient materials will further promote the development of coherent tissues within the printed 3D constructs. For the long term, this work aims to generate bioinks for the development of clinically relevant tissue models.

透明质酸（HA）是人体细胞外基质的主要组成部分，然而，到目前为止，用于生物制造的高用途HA基材料还很缺乏。该项目的总体目标是开发一个基于ha的生物连接平台，利用多功能交联剂（PEG，改性生物聚合物），使间充质干细胞的可控分化成为可能。多肽和生长因子修饰以及加工成梯度材料将进一步促进打印3D结构内连贯组织的发展。从长远来看，这项工作旨在为临床相关组织模型的发展产生生物链接。