Thermo-gelling poly(2-oxazolin) based hydrogels with temporal mechanical control (A03+)

具有时间机械控制的热凝胶聚（2-恶唑啉）基水凝胶（A03）

• 批准号: 397978692
• 金额: --
• 依托单位: Kemian osasto
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/397978692?language=en
• 关键词: Thermo; gelling; poly; oxazolin; based

This Project aims at developing a synthetic, cell-compatible and modular bioink-platform. Diblock copolymers based on poly(2-oxazoline)s will be deployed exhibiting suitable thermo- and shearre-sponsive behavior. This novel bioink platform will be modified by a dual-crosslinking mechanism to (i) guarantee mechanical stability after printing and (ii) to modulate the stiffness of the ink during cell-culture experiments.

该项目旨在开发一种合成的、细胞兼容的、模块化的生物墨水平台。基于聚(2-恶唑啉)S的两嵌段共聚物将被部署，表现出适当的热响应和剪切响应行为。这种新型的生物墨水平台将通过双交联机制进行改进，以(I)保证打印后的机械稳定性和(Ii)在细胞培养实验期间调节墨水的硬度。