Self-Assembled Polymer Nanocontainers – Stimuli Responsive Systems for Controlled Drug Release and Cooperative Catalysis (B19*)

自组装聚合物纳米容器 – 用于控制药物释放和协同催化的刺激响应系统 (B19*)

• 批准号: 398186226
• 金额: --
• 依托单位: Organisch-Chemisches Institut
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/398186226?language=en
• 关键词: Self; Assembled; Polymer; Nanocontainers; Stimuli

In joint efforts of the projects B01, B04 and B06, redox-responsive polymer nanocontainers have been prepared during the 2nd funding period by self-assembly of functional co-polymers on vesicle templates in aqueous solution. These systems have been successfully used for the delivery of hydrophilic cargo into cells and a subsequent efficient intracellular release. In the 3rd period, light-responsive nanocontainers will be assembled. Light as a trigger combines the advantages of a precise spatial and temporal manipulation and this approach represents an elegant way of introducing both hydrophilic and hydrophobic cargo into cells. A further objective is the preparation of colloidal capsules based on polymer decorated vesicles. The preparation of nanocapsules with densely packed colloidal nanoparticles in their shell holds great promise for the tailor-made synthesis of functional materials that will be applied as cooperative catalysts in synthesis.

在项目B01、B04和B06的共同努力下，在第二个资助期内，通过在水溶液中的囊泡模板上自组装功能共聚物，制备了氧化还原响应聚合物纳米容器。这些系统已成功地用于将亲水性货物递送到细胞中以及随后的有效细胞内释放。在第三阶段，将组装光响应纳米容器。光作为触发器结合了精确的空间和时间操作的优点，这种方法代表了将亲水性和疏水性货物引入细胞的优雅方式。另一个目的是制备基于聚合物修饰的囊泡的胶体胶囊。制备在其壳中具有密集填充的胶体纳米颗粒的纳米胶囊对于将在合成中用作合作催化剂的功能材料的量身定制的合成具有很大的希望。