Self-Assembled Polymer Nanocontainers – Stimuli Responsive Systems for Controlled Drug Release and Cooperative Catalysis (B19*)

在B01、B04和B06项目的共同努力下，通过在水溶液中的囊泡模板上自组装功能共聚聚合物，在第二个资助期内制备了氧化还原响应型聚合物纳米容器。这些系统已经成功地用于将亲水性货物输送到细胞内，并随后有效地在细胞内释放。在第三阶段，光响应型纳米容器将被组装。光作为触发器结合了精确的空间和时间操纵的优势，这种方法代表了一种将亲水性和疏水性货物引入细胞的优雅方式。另一个目标是制备以聚合物修饰囊泡为基础的胶体胶囊。壳层中密实填充胶体纳米粒子的纳米胶囊的制备为量身定做的功能材料的合成提供了巨大的希望，这些功能材料将作为合作催化剂应用于合成。

In joint efforts of the projects B01, B04 and B06, redox-responsive polymer nanocontainers have been prepared during the 2nd funding period by self-assembly of functional co-polymers on vesicle templates in aqueous solution. These systems have been successfully used for the delivery of hydrophilic cargo into cells and a subsequent efficient intracellular release. In the 3rd period, light-responsive nanocontainers will be assembled. Light as a trigger combines the advantages of a precise spatial and temporal manipulation and this approach represents an elegant way of introducing both hydrophilic and hydrophobic cargo into cells. A further objective is the preparation of colloidal capsules based on polymer decorated vesicles. The preparation of nanocapsules with densely packed colloidal nanoparticles in their shell holds great promise for the tailor-made synthesis of functional materials that will be applied as cooperative catalysts in synthesis.