Defining the role of hepatocellular carcinoma-related epigenetic alterations driving immune evasion (07)

定义肝细胞癌相关表观遗传改变驱动免疫逃避的作用 (07)

• 批准号: 398473610
• 金额: --
• 依托单位: Medizinische Klinik I
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/398473610?language=en
• 关键词: Defining; role; hepatocellular; carcinoma; related

Epigenetic alterations frequently occur in liver cancer and significantly impair tumor-directed immune responses by both, facilitating resistance to the attack of cytotoxic immune cells while concomitantly modulating function and composition of immune cells in the tumor microenvironment. Based on the potential reversibility of epigenetic modifications and, thus, epigenetic driven immune escape mechanisms the characterization of these mechanisms might be of particular importance for the development of novel therapeutic approaches. Here, we will analyze the role of two HCC-associated key epigenetic regulators, DNMT1 and SIRT6, and their related modifications in tumor-directed immune responses

表观遗传学改变经常发生在肝癌中，并显著损害两者的肿瘤导向免疫应答，促进对细胞毒性免疫细胞攻击的抵抗，同时伴随调节肿瘤微环境中免疫细胞的功能和组成。基于表观遗传修饰的潜在可逆性以及表观遗传驱动的免疫逃逸机制，这些机制的表征对于开发新的治疗方法可能特别重要。在这里，我们将分析两个HCC相关的关键表观遗传调节因子DNMT1和SIRT6的作用，以及它们在肿瘤导向免疫应答中的相关修饰。