Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus

人诱导多能干细胞来源的肝细胞系作为宿主与乙型肝炎病毒相互作用的新模型

• 批准号: 15K15285
• 负责人: Asahina Yasuhiro
• 金额: $ 2.33万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K15285/
• 关键词: HBV; Human iPS cell; cccDNA; iPS細胞; B型肝炎ウイルス; NTCP; 肝幹・前駆細胞; 幹細胞分化

项目成果

Expression of IFN lambda 4 in liver is closely associated with non-response to antiviral therapy through the regulation of basal expression of ISGs in chronic hepatitis C patients but not in hepatitis B.

肝脏中 IFN lambda 4 的表达通过调节慢性丙型肝炎患者 ISG 的基础表达与抗病毒治疗无反应密切相关，但在乙型肝炎中则不然。

• 发表时间: 2015
• 作者: Murakawa M;Asahina Y;Kawai-Kitahata F;Nagata H;Kaneko S;Nitta S;Watanabe T;Itsui Y;Nakagawa M;Kakinuma S;Iijima S;Tanaka Y;Watanabe M;Tanaka Y
• 通讯作者: Tanaka Y

Effects of Resistance-Associated NS5A Mutations in Hepatitis C Virus on Viral Production and Susceptibility to Antiviral Reagents.

• DOI: 10.1038/srep34652
• 发表时间: 2016-10-05
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Nitta S;Asahina Y;Matsuda M;Yamada N;Sugiyama R;Masaki T;Suzuki R;Kato N;Watanabe M;Wakita T;Kato T
• 通讯作者: Kato T

Complex Pattern of Resistance-Associated Substitutions of Hepatitis C Virus after Daclatasvir/Asunaprevir Treatment Failure.

• DOI: 10.1371/journal.pone.0165339
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Itakura J;Kurosaki M;Hasebe C;Osaki Y;Joko K;Yagisawa H;Sakita S;Okushin H;Satou T;Hisai H;Abe T;Tsuji K;Tamada T;Kobashi H;Mitsuda A;Ide Y;Ogawa C;Tsuruta S;Takaguchi K;Murakawa M;Asahina Y;Enomoto N;Izumi N
• 通讯作者: Izumi N

Human induce pluripotent stem cell-dereived hepatic progenitor-like cells and hepatocyte-like cells as a model for interaction between hepatitis B virus and host cells.

人类诱导多能干细胞来源的肝祖细胞样细胞和肝细胞样细胞作为乙型肝炎病毒与宿主细胞之间相互作用的模型。

• 发表时间: 2015
• 作者: Kaneko S;Kakinuma S;Asahina Y;Kamiya A;Nitta S;Tsunoda T;Miyosi M;Nagata H;Goto F;Otani S;Murakawa M;Kawai-Kitahata F;Itsui Y;Nakagawa M;Azuma S;Watanabe M
• 通讯作者: Watanabe M

Effects of resistance mutations of NS5A inhibitor on viral production and susceptibility to anti-HCV reagents in recombinant hepatitis C viruses with NS5A of genotype 1b.

NS5A 抑制剂耐药突变对基因型 1b NS5A 重组丙型肝炎病毒中病毒产生和抗 HCV 试剂敏感性的影响。

• 发表时间: 2015
• 作者: Nitta S;Asahina Y;Wakita T;Kato T
• 通讯作者: Kato T