Measurement of mechanical properties of the cell nucleus for an exhaustive evaluation of stem cell differentiation

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In this study, the microcavity array which enables entrapment of 10, 000 single cells with high efficiency was utilized for the quantitative evaluation of cellular deformability. A quantitative measurement procedure of the three dimensional image of the cells trapped on the microcavity array by image analysis using the confocal microscopy was established. Using these techniques, cellular deformability of normal cells and cancer cells were quantitatively evaluated for considering the correlation between their deformability and progress degrees of differentiation or canceration.