Identification and functional analysis of chondroitin proteoglycans involved in early cell division of the nematode C. elegans

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Our discovery of involvement of chondroitin proteoglycans in early cell division of the nematode Caenorhabditis elegans (Nature 2003) opened up a new chapter in glycobiology, but the molecular mechanism of their involvement in cell cycle progression remains unknown. In this study, I tried to identify novel chondroitin-core proteins, and found that the chondroitin proteoglycans are involved in meiosis as well as in mitosis of the nematode. The identification of the novel gene network sheds new light on the roles of proteoglycans in cell cycle control.