Development of Scanning Optical Resonance Cavity RamanMicroscope and its Application to the Monitoring the Response of Cell under Mechanical Stimuli

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To obtain interface-selective Raman signals from a single living cell under mechanical stimuli, we have developed a scanning optical resonance cavity Raman microscope. To change the probe to one with a non-contact manner, we applied an optical pressure by laser-beam irradiation for probing the mechanical response of a single living cell at optional points utilizing a microscope. The newly developed original microscope enables us to measure the viscoelasticity of a single cell with a non-contact manner. In addition, resonant Raman signals were detected under the same microscope, which will provide information on the molecular origin of viscoelasticity in a single living cell