Clarification of the molecular mechanisms that degitize Wnt signaling.

在脊椎动物组织的轴形成过程中，细胞感知Wnt配体的浓度，并将其信息转化为数字信息，指导选择性基因表达的调控。在本研究中，我们研究了Wnt信号转导-脱数字化系统，发现DP1蛋白参与了该系统。我们还建立了新的实验系统来观察活体动物的Wnt信号活动。

During axis-formation in vertebrate tissues, cells sense the concentration of Wnt ligands and convert its information into the digital information that directs the regulation of selective gene expression. In this study, we investigated this Wnt signaling-degitizing system and found that DP1 protein is involved in this system. We also generated the new experimental systems for observing Wnt signaling activity in living animals.