Identification of factors associated with drug-therapy resistance by pheripheral blood serum cell-free nucleotic acids

外周血血清游离核酸鉴定耐药相关因素

• 批准号: 26670695
• 负责人: Habuchi Tomonori
• 金额: $ 2.41万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-26670695/
• 关键词: 腎癌; 膀胱癌; エキソソーム; 分子標的薬; 液性生検; PAI-1; miR-21; 腎細胞癌; 尿路上皮癌; microRNA; アキシチニブ; エクソソーム; miRNA; バイオマーカー; 泌尿器癌; Liquid Biopsy; 前立腺癌; DNA; RNA

项目成果

Exosomal miRNAs and serum cytokines as predictors for treatment outcomes in patients with metastatic renal cell carcinoma treated with axitinib

外泌体 miRNA 和血清细胞因子作为阿西替尼治疗转移性肾细胞癌患者治疗结果的预测因子

• 发表时间: 2016
• 作者: Naoko Suzuki-Honma*;Akita;Japan;Norihiko Tsuchiya;Yamagata;Japan;Takamitsu Inoue;Shintaro Narita;Mitsuru Saito;Hiroshi Tsuruta;Atsushi Maeno;Shigeru Satoh;Tomonori Habuchi
• 通讯作者: Tomonori Habuchi

Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.

• DOI: 10.1158/1055-9965.epi-14-0317
• 发表时间: 2015-07
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Amin Al Olama A;Benlloch S;Antoniou AC;Giles GG;Severi G;Neal DE;Hamdy FC;Donovan JL;Muir K;Schleutker J;Henderson BE;Haiman CA;Schumacher FR;Pashayan N;Pharoah PD;Ostrander EA;Stanford JL;Batra J;Clements JA;Chambers SK;Weischer M;Nordestgaard BG;Ingles SA;Sorensen KD;Orntoft TF;Park JY;Cybulski C;Maier C;Doerk T;Dickinson JL;Cannon-Albright L;Brenner H;Rebbeck TR;Zeigler-Johnson C;Habuchi T;Thibodeau SN;Cooney KA;Chappuis PO;Hutter P;Kaneva RP;Foulkes WD;Zeegers MP;Lu YJ;Zhang HW;Stephenson R;Cox A;Southey MC;Spurdle AB;FitzGerald L;Leongamornlert D;Saunders E;Tymrakiewicz M;Guy M;Dadaev T;Little SJ;Govindasami K;Sawyer E;Wilkinson R;Herkommer K;Hopper JL;Lophatonanon A;Rinckleb AE;Kote-Jarai Z;Eeles RA;Easton DF;UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology;UK ProtecT Study Collaborators;PRACTICAL Consortium
• 通讯作者: PRACTICAL Consortium

Stabilization of invadopodia by plectin-mediated conjunction to vimentin intermediate filament is a critical molecular step of invasion and extravasation for metastasis in bladder cancer.

通过凝集素介导的与波形蛋白中间丝的结合来稳定侵袭伪足是膀胱癌转移侵袭和外渗的关键分子步骤。

• 发表时间: 2016
• 作者: Yoneyama MS;Hatakeyama S;Habuchi T;Inoue T;Nakamura T;Funyu T;Wiche G;Tsuboi S; Ohyama C
• 通讯作者: Ohyama C

Expression of steroid hormone receptors in residual cancer and stromal cells after neoadjuvant chemohormonal therapy with docetaxal for high-risk localized prostate cancer.

使用多西紫杉醇新辅助化学激素治疗高危局限性前列腺癌后残留癌和基质细胞中类固醇激素受体的表达。

• 发表时间: 2016
• 作者: Narita;S.;Nara;T.;Huang;M.;Numakura;K.;Tsuruta;H.;Maeno;A.;Saito,M.;Inoue;T.;Tsuchiya;N.;Nanjo;H.;Satoh,S.;Habuchi;T.
• 通讯作者: T.

進行性腎癌におけるアキシチニブの効果予測を目的とした血清バイオマーカーの探索

寻找血清生物标志物来预测阿西替尼对晚期肾癌的疗效

• 发表时间: 2016
• 作者: 本間直子;土谷順彦;井上高光;鶴田大;前野淳;沼倉一幸;成田伸太郎;齋藤満;佐藤滋;羽渕友則;五十嵐 龍馬;喜早 祐介
• 通讯作者: 喜早 祐介