Classification of antiarrhythmic drugs from the effect on cardiac excitability

从心室兴奋性的角度提出了抗心律失常药物的分类。通过50个HRZ的阳极刺激和阳极序列脉冲获得以下参数：相对不应期RRP(阈值为1 mA)、舒张期内阈值(EDT)、超常周期(CSP)、DIP现象(DP)和室颤阈值(VFI)(由小于电流强度1 mA的50个HRZ序列脉冲持续1.8秒确定)。E组包括利多卡因，B组包括普鲁卡因胺。RRP(1 MA)EDT DP和SP VFT(延长)(增加)(增加)(消失)(增加)A---B--C-D-E

The classification of antiarrhythmic drugs was proposed from the standpoint of ventricular excitability. The following parameters for this purpose were obtained by the anodal stimulation and anodal train pulses of 50 Hrz; relative refractory period RRP (threshold was 1mA),endodiastolic threshold (EDT), supernormal period (CSP), dip phenomenon(DP) and ventricular fibrillation threshold (VFI) which was determined by the 50 Hrz train pulses less than the current intensity of 1 mA and the duration of 1.8 sec.The antiarrhythmic drugs may be classified into 5 groups by these parameter in the table. Lidocaine was included in E grorp, Procaineamid in B for example.RRP(1mA) EDT DP ＆ SP VFT(prolonged) (increased) (disappear) (increased)A + - - -B + - - +C + + - +D + - + +E + + + +