Application of models of spasticity and spastic paralysis

丘间去大脑强直（所谓<gamma>的-强直）和贫血性去大脑强直（<alpha>-强直）已用于猫的药理学和生理学研究。因为大鼠通常用于行为和神经化学研究，因为它们易于处理，然而，我们已经使用大鼠在评价中枢作用的肌肉松弛剂中产生了两种类型的僵硬（Fukuda等人，1974; Togari等人，1978).丘间去大脑强直的成功率不高，可能是由于出血压迫大脑或难以精确控制压舌板。为了避免上述问题，本研究采用射频毁损大鼠中脑，以获得良好的去脑强直模型，并建立一种简便的去脑强直模型，研究了氯丙嗪（chlorpromazine，CPZ）和美芬甘肽（mephenesin，一种中枢性肌松药）对大鼠去脑强直模型的影响.本研究采用大鼠双侧中脑射频毁损的方法，试图建立一种无出血的去大脑强直模型.明显的伸肌强直发生在后肢的高reproducibillity没有出现自愿运动。采用后足重复背屈引起的牵张反射张力作为刚度强度的测量。CPZ-HCL（0.1-1 mg/kg，i.v.）和美芬甘油醚（10-50 mg/kg，i. v.）降低丘间去脑刚度，降低RF去脑刚度.这些结果表明，RF去大脑刚度可以用来代替丘间横断刚度的药理学和生理学研究。

Intercollicular decerebrate rigidity (so-called <gamma> -rigidity) and anaemic decerebrate rigidity ( <alpha> -rigidity) have been used in pharmacological and physiological studies in cats. Because rats are usually used in behavioural and neurochemical studies for their ease of handling, however, we have produced both types of rigidity using rats in the evalustion of centrally acting muscle relaxants (Fukuda et al., 1974; Togari et al., 1978).The rate of success of intercollicular decerebrate rigidity has not been high probably due to compression of the brain by bleeding or the difficulty involved in precisely controlling the spatula. In order to avoid such problems, radio frequency (RF) lesion of the midbrain was produced in attempts to obtain a good preparation of rigidity and to establish an easy method of decerebration in rats.The effects of chlorpromazine (CPZ), a frug which preferentially depresses intercollicular decerebrate rigidity, and mephenesin, a centrally acting muscle relaxant, were evaluated on the RF decerebrate rigidity.1. Bilateral RF lesions of the midbrain were produced in an attempt to establish a non-bleeding method of producing decerebrate rigidity in rats.2. Marked extensor rigidity occurred with a high reproducibillity in hindlimbs without the appearance of voluntary movement. Stretch reflex tension induced by repetitive dorsiflexion of the hindfeet was employed as a measure of the intensity of rigidity.3. CPZ-HCL (0.1-1 mg/kg, i.v.) and mephenesin (10-50 mg/kg, i.v.) which depress intercollicular decerebrate rigidity, reduced the RF decerebrate rigidity.4. These results suggest that RF decerebrate rigidity can be used instead of intercollicular transection rigidity in the pharmacological and physiological studies.