Studies on Scientific Elucidation of Smuggling Routes for Methamphetamine

科学查明冰毒走私路线研究

• 批准号: 60870099
• 负责人: MIURA Yoshiro
• 金额: $ 1.6万
• 依托单位: Teikyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60870099/
• 关键词: stimulant; drug fingerprint; methamphetamine; amphetamine; amphetamine; ヒロポン; methamphetamineヒロポンのdl分割; ヒロポンの生体内動態

Although the use and possession of methamphetamine are prohibited by the Japanese regulations for methamphetamine, methamphetamine has been smuggled from abroad at present. Methamphetamine is smuggled as the powder form. We have attempted to elucidate the route of smuggling and illicit sale of methamphetamine.1. The resolution of optical isomers(d- and l-form) of methamphetamine by high performance liquid chromatography(HPLC) was studied. The acetylated derivative of methamphetamine was subjected to a column of the cellulose derivative at 40゜C. The solvent system was hexane/isopropanol(19:1). The d- and l-isomers of methamphetamine were clearly separated by HPLC with good reproductivity.2. All methamphetamine smuggled from Korea is its hydrochloride form (mp. 170-175゜C). The optical purity of the methamphetamine from Korea is 100% for d-isomer, but it contained yellow crystal. This contamination of yellow crystal may be used as the criterion for the drug transportation. Since we obtain … More ed a permission for the synthesis of methamphetamine from a minister of the Ministry of Health, we tried to isolate the d-isomer of methamphetamine from the racemic methamphetamine and obtained almost pure d-isomer (mp. 133゜C). Our results suggest that the d/l ratio of methamphetamine can be used as a drug fingerprint like the fingerprint which has been used for personal identification at criminal investigations. The accumulated data concerning the drug fingerprint (the d/l ratio) of the methamphetamine seized at various places can be used for the scientific elucidation of the illict and smuggling routes of methamphetamine in the future.3. The metabolism and disposition of methamphetamine were investigated using laboratory animals. Our results showed clearly that the d-isomer of methamphetamine had stronger pharmacological activity than the l-isomer and both isomers were detected from solid tissues such as bones, teeth or hair. It was also found that the administration of methamphetamine induced the Waterhouse-Friderichsen-Syndrome. Less

虽然日本关于甲基安非他明的条例禁止使用和拥有甲基安非他明，但目前仍有从国外走私甲基安非他明的现象。甲基苯丙胺以粉末形式走私。我们已尝试厘清走私及非法销售甲基安非他明的途径。研究了高效液相色谱法拆分甲基苯丙胺光学异构体（d型和l型）的方法。甲基苯丙胺的乙酰化衍生物在40 ℃下经受纤维素衍生物柱。溶剂系统为己烷/异丙醇（19：1）。甲基苯丙胺的左旋和右旋异构体分离清晰，重现性好.所有从韩国走私的甲基苯丙胺都是盐酸盐形式（mp。170-175 ℃）。来自韩国的甲基苯丙胺的光学纯度为100%的d-异构体，但含有黄色晶体。这种黄色晶体的污染可以作为药物运输的标准。由于我们获得 ...更多信息 艾德从卫生部的一位部长那里获得了合成甲基苯丙胺的许可，我们试图从外消旋甲基苯丙胺中分离出甲基苯丙胺的d-异构体，并获得了几乎纯的d-异构体（mp. 133摄氏度）。我们的研究结果表明，甲基苯丙胺的d/l比可以作为一个药物指纹，指纹已被用于在刑事调查中的个人识别。积累的关于在各地缉获的甲基苯丙胺的药物指纹（d/l比率）的数据可用于将来科学地阐明甲基苯丙胺的非法和走私路线。使用实验动物研究了甲基苯丙胺的代谢和处置。我们的结果清楚地表明，甲基苯丙胺的d-异构体比l-异构体具有更强的药理活性，并且这两种异构体都从固体组织如骨骼、牙齿或毛发中检测到。还发现甲基苯丙胺的施用诱导了Waterhouse-Friderichsen综合征。少

项目成果

Tasuo Nagai, Toshiaki Nagai and Yoshiro Miura: "Experimental model of drug abuse. Detection of methamphetamine from solid tissues of experimental animal and man" Kliminalstik und forens. Wiss.

Tasuo Nagai、Toshiaki Nagai 和 Yoshiro Miura：“药物滥用实验模型。从实验动物和人的实体组织中检测甲基苯丙胺”Kliminalstik und forens。

長井敏明,高橋雅典,上山滋太郎,長井辰男: 第71回日本法医学会総会(東京,1987).

Toshiaki Nagai、Masanori Takahashi、Shigetaro Ueyama、Tatsuo Nagai：日本法医学会第 71 届大会（东京，1987 年）。

Tatsuo Nagai and Toshiaki Nagai: "A new diagnostic method for detection addiction and its value in disaster" 4th World Congress on Emergency and Disaster Medicine (Brighton, England). (1985)

Tatsuo Nagai 和 Toshiaki Nagai：“检测成瘾的新诊断方法及其在灾难中的价值”第四届世界急诊和灾难医学大会（英国布莱顿）。

26th Congress of the European Society of Toxicology. (1985)

欧洲毒理学会第 26 届大会。

Tatsuo Nagai: "Experimental model of the Waterhouse-Friderichsen Syndrome induced with methamphetamine" Symposium on Validity of Animal Experiments in Teaching Pharmacology and Toxicology (Helsinki, Finland). (1985)

Tatsuo Nagai：“用甲基苯丙胺诱导的 Waterhouse-Friderichsen 综合征的实验模型”药理学和毒理学教学中动物实验有效性研讨会（芬兰赫尔辛基）。