環境適応行動における機能連関解析装置の開発

构建了警觉猴不同稳态功能（体温调节、饮水和摄食）的操作行为和速率的多功能分析系统。该系统可接受三种不同的行为输入（按杆、声音和实验动物心率的变化），并可给予动物不同的奖励（凉爽或温暖的空气、食物、果汁、水或脑奖励系统的电刺激，具体取决于实验时间表）。该系统具有半自动训练操作行为的功能。此外，该系统还可以记录和分析警觉动物中枢神经系统中与行为行为相关的神经元活动。采用第三系统对高固定日粮（FR=30）时猕猴下丘脑神经元的体温调节冷却行为和摄食行为进行了分析。至少在冷却行为的一个阶段改变活动的神经元数量在温度敏感神经元中显著高于非温度感知神经元。最常观察到的反应是在bar按压期间和/或冷却期间活动的持续增加或减少。与bar压力机相关的活动并不是一种完全不耦合的反应，但它的强度被动物寻求凉爽空气的动机的强度大大改变了。与冷却阶段相关的活动不是简单的热感反应，而是依赖于冷却空气的再加热值。这些结果表明，下丘脑视前区的热敏感神经元参与了温度调节冷却行为的控制。一些在冷却行为中有反应的神经元也改变了进食行为的活动。利用微丝（铂-钛）技术成功地记录了下丘脑自由运动速率下单个神经元的活动，并对神经元活动与行为的关系进行了分析。少

A multi-purposes analyzing system fro operant begaviors of different homeostatic functions (theromrequlation, driking and feeding) of alert monkeys and rate was constructed. This system may accept three different kinds of behavioral inputs (bar pressing, voice and changes in heart rate of experimental animals) and may give animals various reqards (cool or warm air, food, juice, water or electrical stimulation of the brain reward system, depending on the experimwental schedule). The system has a facility of semi-automatic training of operant behaviors. Moreover, the system allows the study of recording and analyzing the activity of neurons in the central nervous system of alert animals in relation to the behaioral actions.The analysis of menkey hypotalamic neurons during high fixed ration (FR=30) thermoregulatory cooling behavior and feeding begavior was performed utilizing thid system. The population of neurons which changed the activity at least in one phase of cooling behavior was si … More gnificantly higher among termosensitive neurons than among non-termosentitice neurons. The most frequantly observed responses were the sustained inci wease or dectrease in activity dfuring the bar press perios and/or the cooling period. The bar press related activity was not a pute morot coupled response, byt its magnitude was greatly modigiied by the sttength of motivation of animals to seek cool air. The cooling phase related activity was not a simple thermosnesory response, but was dependent on the rewatding value of the cooling air. The results suggest that hermosnesitive neurons in the preoptic hypothalamus is novlved in the control of thermoregulatory cooling behariov. Some neurons which responded during the cooling behabvior also changed the activity furing the feeding behavior.Single neuron activity in the hypotalamus of free moving rate was successfully recorded by a microwire (platinum-itidium) rechnique, and the analsys of the neuronal activity in relation to behaviors is now under way. Less