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環境適応行動における機能連関解析装置の開発

环境适应行为函数关系分析装置研制

基本信息

批准号：
61870010
负责人：
TETSURO HORI
金额：
$ 4.86万
依托单位：
Saga Medical Schoo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

项目摘要

A multi-purposes analyzing system fro operant begaviors of different homeostatic functions (theromrequlation, driking and feeding) of alert monkeys and rate was constructed. This system may accept three different kinds of behavioral inputs (bar pressing, voice and changes in heart rate of experimental animals) and may give animals various reqards (cool or warm air, food, juice, water or electrical stimulation of the brain reward system, depending on the experimwental schedule). The system has a facility of semi-automatic training of operant behaviors. Moreover, the system allows the study of recording and analyzing the activity of neurons in the central nervous system of alert animals in relation to the behaioral actions.The analysis of menkey hypotalamic neurons during high fixed ration (FR=30) thermoregulatory cooling behavior and feeding begavior was performed utilizing thid system. The population of neurons which changed the activity at least in one phase of cooling behavior was si … More gnificantly higher among termosensitive neurons than among non-termosentitice neurons. The most frequantly observed responses were the sustained inci wease or dectrease in activity dfuring the bar press perios and/or the cooling period. The bar press related activity was not a pute morot coupled response, byt its magnitude was greatly modigiied by the sttength of motivation of animals to seek cool air. The cooling phase related activity was not a simple thermosnesory response, but was dependent on the rewatding value of the cooling air. The results suggest that hermosnesitive neurons in the preoptic hypothalamus is novlved in the control of thermoregulatory cooling behariov. Some neurons which responded during the cooling behabvior also changed the activity furing the feeding behavior.Single neuron activity in the hypotalamus of free moving rate was successfully recorded by a microwire (platinum-itidium) rechnique, and the analsys of the neuronal activity in relation to behaviors is now under way. Less

本文建立了一个多功能分析系统，用于分析警觉猴的不同稳态功能（热调节、饮水和进食）的操纵因子和心率。该系统可以接受三种不同类型的行为输入（压杆、声音和实验动物心率的变化），并可以给动物各种要求（冷或热空气、食物、果汁、水或大脑奖励系统的电刺激，取决于实验时间表）。该系统具有操作行为半自动训练的功能。此外，该系统还可用于记录和分析警觉动物中枢神经系统神经元活动与行为的关系，并应用该系统分析了高固定比率（FR=30）时雄性动物体温调节降温行为和摄食行为时下丘脑神经元的活动。至少在冷却行为的一个阶段改变活动的神经元的数量是相同的。 ...更多信息温度敏感性神经元中的这种变化显著高于非温度敏感性神经元。最常见的反应是在压棒期间和/或冷却期间活动的持续增加或减少。与压杆相关的活动不是一个简单的耦合反应，拜特其强度受动物寻求冷空气动机强度的影响。与冷却相有关的活动不是简单的热响应，而是依赖于冷却空气的加热值。结果提示，下丘脑视前区热敏感神经元参与体温调节降温行为的控制。用铂-铱微丝技术成功地记录了自由运动速率下丘脑单个神经元的活动，并对神经元活动与行为的关系进行了分析。少