Functional characterization of the atypical member of the IkappaB inhibitor Bcl-3 in pancreatic ductal adenocarcinoma (P04)

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The atypical member of the Inhibitor of kappa-B (IkappaB) family of proteins B-cell CLL/lymphoma 3 (Bcl-3) is an established oncogene in hematologic malignancies. Here we demonstrate for the first-time hyperphosphorylation of Bcl-3 in human and murine PDAC. Using various genetic tools we report that hyperphosphorylated Bcl-3 negatively regulates pancreatic carcinogenesis and metastasis. We will elaborate the previously unrecognized role for Bcl-3 and its phosphorylated sites in PDAC and highlight new aspects of Bcl-3 in this disease.