Dissecting Toll-like receptor 3 function in pancreatic regeneration and neoplastic transformation (P05)

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The Toll-like receptor (TLR) pathways are frequently altered at the genetic level in PDAC. Based on this and our own preliminary work, which shows a defective pancreatic regeneration and pronounced Kras-driven inflammation in the context of TLR3 loss, we hypothesize that the nucleic acid sensor TLR3 plays an essential and compartment-specific role during regeneration and carcinogenesis in the pancreas. In this research initiative, we aim to dissect the specific role of TLR3 in these processes. The overall aim is to identify new druggable pathways that critically influence pancreatic tumorigenesis.