Dissecting Toll-like receptor 3 function in pancreatic regeneration and neoplastic transformation (P05)

解析 Toll 样受体 3 在胰腺再生和肿瘤转化中的功能 (P05)

• 批准号: 403606414
• 金额: --
• 依托单位: Klinik und Poliklinik für Chirurgie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/403606414?language=en
• 关键词: Dissecting; Toll; like; receptor; function

The Toll-like receptor (TLR) pathways are frequently altered at the genetic level in PDAC. Based on this and our own preliminary work, which shows a defective pancreatic regeneration and pronounced Kras-driven inflammation in the context of TLR3 loss, we hypothesize that the nucleic acid sensor TLR3 plays an essential and compartment-specific role during regeneration and carcinogenesis in the pancreas. In this research initiative, we aim to dissect the specific role of TLR3 in these processes. The overall aim is to identify new druggable pathways that critically influence pancreatic tumorigenesis.

Toll样受体（TLR）通路在PDAC中经常在遗传水平上改变。基于这一点和我们自己的初步工作，这表明有缺陷的胰腺再生和明显的Kras驱动的炎症在TLR3损失的背景下，我们假设核酸传感器TLR3在胰腺再生和癌变过程中起着重要的和隔室特异性的作用。在这项研究中，我们的目标是剖析TLR3在这些过程中的具体作用。总的目标是确定新的药物途径，严重影响胰腺肿瘤的发生。