Dissecting the role of metabolic alterations in sphingolipids in PDAC (P14)

剖析 PDAC 中鞘脂代谢改变的作用 (P14)

• 批准号: 403834633
• 金额: --
• 依托单位: Medizinische Klinik und Poliklinik II - Großhadern
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/403834633?language=en
• 关键词: Dissecting; role; metabolic; alterations; sphingolipids

Sphingolipids, such as ceramide, and sphingosine-1-phosphate (S1P), have opposing roles in PDAC carcinogenesis. However, cellular and molecular determinants regulating selectivity of sphingolipid metabolites are poorly understood. We aim (1) to understand the pancreas specific role of sphingomyelin metabolism. (2) To understand the relationship of metabolic changes in the sphingolipid pathway in its cellular context. (3) To understand the contribution of compensatory sphingolipid pathways for membrane fluidity acting as triggers for neoplastic transformation and treatment resistance.

鞘磷脂，如神经酰胺和鞘氨醇-1-磷酸(S1P)，在PDAC的致癌过程中具有相反的作用。然而，调节鞘磷脂代谢物选择性的细胞和分子决定因素却知之甚少。我们的目标是(1)了解神经鞘蛋白代谢在胰腺中的特殊作用。(2)了解鞘磷脂途径代谢变化与细胞环境的关系。(3)了解鞘磷脂代偿通路对细胞膜流动性的影响，作为肿瘤转化和治疗耐药的触发因素。