Elucidation of bioavailability and anticancer property of momilactones and natural anticancer compounds isolated from rice

阐明从大米中分离的莫米内酯和天然抗癌化合物的生物利用度和抗癌特性

基本信息

  • 批准号:
    21K14818
  • 负责人:
  • 金额:
    $ 2.91万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
  • 财政年份:
    2021
  • 资助国家:
    日本
  • 起止时间:
    2021-04-01 至 2025-03-31
  • 项目状态:
    未结题

项目摘要

The cytotoxic mechanism of momilactones A (MA) and B (MB) against blood cancer cell lines including acute promyelocytic leukemia and multiple myeloma were clarified. Of which, According to MTT results, MB and the mixture MAB (1:1, w/w) show a substantial inhibition on the cell viability of HL-60 and U266, with IC50 ranging from 4.49 to 5.59 uM. Besides, MB and MAB at 5 uM inhibit HL-60 cells through the regulations of relevant proteins to apoptosis-inducing factors (p-38, BCL-2, and caspase-3) and cell cycle arrest at G2 phase (p-38, CDK1, and cyclin B1). Meanwhile, these compounds enhance U266 apoptosis by altering p-38, BCL-2, and caspase-3 signaling pathways. Significantly, momilactones exhibit a minor effect on a non-cancerous cell line (MeT-5A), implying that they are promising candidates for developing novel anti-APL and anti-MM medicines. The results were published on Cancers. In addition, the effects of in vitro digestion on anti-blood cancer and bioaccessibility of MA and MB were investigated. Results reveal that the cytotoxic activities of MB and MAB were dramatically decreased. In addtition, the bioaccessibility of momilactones was significantly reduced (from 28.44% to 75.14%) which was strongly correlated with their decreased cytotoxicity under digestion. The findings were presented at the 2023 Annual Meeting of the Japan Society for Bioscience, Biotechnology, and Agrochemistry (日本農芸化学会2023年度大会), Online meeting, March 2023.
The cytotoxic mechanism of momilactones A (MA) and B (MB) against blood cancer cell lines including acute promyelocytic leukemia and multiple myeloma were clarified. Of which, According to MTT results, MB and the mixture MAB (1:1, w/w) show a substantial inhibition on the cell viability of HL-60 and U266, with IC50 ranging from 4.49 to 5.59 uM. Besides MB and MAB at 5 uM inhibit HL-60 cells through the regulations of relevant proteins to apoptosis-inducing factors (p-38, BCL-2, and caspase-3) and cell cycle arrest at G2 phase (p-38, CDK1, and cyclin B1). Meanwhile, these compounds enhance U266 apoptosis by altering p-38, BCL-2, and caspase-3 signaling pathways. Significantly, momilactones exhibit a minor effect on a non-cancerous cell line (MeT-5A), implying that they are promising candidates for developing novel anti-APL and anti-MM medicines. The results were published on Cancers. In addition, the effects of in vitro digestion on anti-blood cancer and bioaccessibility of MA and MB were investigated. Results reveal that the cytotoxic activities of MB and MAB were dramatically decreased. In addtition, the bioaccessibility of momilactones was significantly reduced (from 28.44% to 75.14%) which was strongly correlated with their decreased cytotoxicity under digestion. The findings were presented at the 2023 Annual Meeting of the Japan Society for Bioscience, Biotechnology, and Agrochemistry (2023 Annual Conference of the Japanese Agrochemistry Society), Online meeting, March 2023.

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Effects of in vitro digestion on momilactones and their anti-blood cancer activity
体外消化对莫米内酯及其抗血癌活性的影响
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Anh La Hoang;Lam Vu Quang;Takami Akiyoshi;Khanh Tran Dang;Quan Nguyen Van;Xuan Tran Dang;La Hoang Anh
  • 通讯作者:
    La Hoang Anh
Anti-blood cancer property of momilactones A and B from rice husks
稻壳中的莫米内酯 A 和 B 的抗血癌特性
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Anh La Hoang;Lam Vu Quang;Takami Akiyoshi;Khanh Tran Dang;Quan Nguyen Van;Xuan Tran Dang;La Hoang Anh;La Hoang Anh
  • 通讯作者:
    La Hoang Anh
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