Differential dopamine dynamics of DMS and DLS projecting SNc neurons during reversal learning

阐明大鼠执行概率奖励任务时DMS和DLS投射SNc神经元的相位活动变化，识别纹状体神经元的直接和间接通路，以及纹状体局部多巴胺释放。我们用TH-Cre、Drd2-Cre和Tac-1-Cre转基因大鼠进行多巴胺能神经元和纹状体突起神经元的鉴定。为了研究多巴胺在背纹状体的释放，我们在DMS和DLS中表达dLight，并使用纤维光度法监测荧光。阐明大鼠执行概率奖励任务时脑内（IT）和皮质（CF） DMS皮质纹状体OFC和mPFC的差异作用。我们使用病毒载体方法来鉴定不同的DMS皮质纹状体神经元。

Elucidation of the changes of the phasic activity of the DMS and DLS projecting SNc neurons, identified direct and indirect pathway striatal neurons, and local striatum dopamine release in rats performing a probabilistic reward-based task. We used TH-Cre, Drd2-Cre and Tac-1-Cre transgenic rats for dopaminergic neurons and striatal projecting neurons identification. For the investigation of dopamine release in dorsal striatum, we express dLight in DMS and DLS and monitored the fluorescence using fiber photometry.Elucidation of the differential role of intratelencephalic (IT) and corticofugal (CF) DMS corticostriatal OFC and mPFC in rats performing a probabilistic reward-based task. We use a viral vector approach for the identification of the different DMS corticostriatal neurons.