Differential dopamine dynamics of DMS and DLS projecting SNc neurons during reversal learning

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Elucidation of the changes of the phasic activity of the DMS and DLS projecting SNc neurons, identified direct and indirect pathway striatal neurons, and local striatum dopamine release in rats performing a probabilistic reward-based task. We used TH-Cre, Drd2-Cre and Tac-1-Cre transgenic rats for dopaminergic neurons and striatal projecting neurons identification. For the investigation of dopamine release in dorsal striatum, we express dLight in DMS and DLS and monitored the fluorescence using fiber photometry.Elucidation of the differential role of intratelencephalic (IT) and corticofugal (CF) DMS corticostriatal OFC and mPFC in rats performing a probabilistic reward-based task. We use a viral vector approach for the identification of the different DMS corticostriatal neurons.