The role of alternative autophagy-related ubiquitin ligase in the pathogenesis of colitis

替代自噬相关泛素连接酶在结肠炎发病机制中的作用

• 批准号: 21K15968
• 负责人: Nibe Yoichi
• 金额: $ 2.91万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K15968/
• 关键词: 炎症性腸疾患; ユビキチン; 新規オートファジー; GOMED; ユビキチンリガーゼ; サイトカイン; オートファジー; 腸炎

项目成果

Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis.

• DOI: 10.1016/j.bbrc.2022.08.046
• 发表时间: 2022-08
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Akiko Tamura;Go Ito;Hiroki Matsuda;Yoichi Nibe-Shirakihara;Y. Hiraoka;Sayuki Kitagawa;Yui Hiraguri-Yui-Hira

Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62.

• DOI: 10.1016/j.bbrc.2021.01.023
• 发表时间: 2021-01
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: E. Aonuma;Akiko Tamura;Hiroki Matsuda;Takehito Asakawa;Y. Sakamaki;Kana Otsubo;Yoichi Nibe;Michio Onizawa;Y. Nemoto;T. Nagaishi;K. Tsuchiya;Tetsuya Nakamura;M. Uo;Mamoru Watanabe;R. Okamoto;S. Oshima