Prevention of Candida-associated denture stomatitis: intervention studies

预防念珠菌相关假牙口腔炎：干预研究

• 批准号: 21K17056
• 负责人: 尾崎 公哉
• 金额: $ 1.75万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K17056/
• 关键词: カンジダ; 義歯; 義歯清掃; 高齢者; 義歯性口内炎; 清掃管理

本研究は①義歯清掃が義歯に付着するカンジダに影響するのか②義歯に付着したカンジダが義歯性口内炎に進行するまでにどれくらいの期間で何が関連するのか③義歯床用レジンを走査型電子顕微鏡で観察し義歯性口内炎との関係を検索することを目的とした。義歯の清掃管理を介入する縦断研究は数多くあるが, 1～3週間程度の短期間の介入であり,長期間にわたる縦断研究の報告はない.そのため高齢社会のなかで急増する要介護高齢者の義歯管理に役立つと考えている。現在は清掃指導を行った群と清掃指導を行わなかった群で、義歯装着時と義歯装着後1, 3, 6, 9, 12か月の時点で経過観察を行い, 各時点で, 切歯乳頭周辺の①義歯粘膜面, ①に相当する②口蓋粘膜, ③義歯装着下の口内リンス液から検体を採取し, クロモアガー培地で培養後, 菌種とコロニー数(CFU/ml) を測定し, 義歯粘膜面からのカンジダ検出の有無と関連因子との関係を検索し、また関連因子については年齢, 性別, 既往疾患数, 常用薬剤数, 安静時唾液分泌量, 口腔乾燥所見(柿木の分類), 義歯の使用歴の有無, 下顎義歯の有無, 義歯清掃状況,義歯装着時のカンジダ保菌の有無, 口腔内総細菌数, 口腔内湿潤度, 検討を行い、二群間で有意な差を認めた。この結果はJournal of Oral and Maxillofacial Surgery, Medicine, and Pathologyにて論文を執筆しアクセプトされた。その後はこの研究にてカンジダ性の義歯性口内炎（発赤）まで発展する症例は認めなかったため、現在カンジダ発赤症例について研究を行い、検討を行っている。

The purpose of this study is to investigate the relationship between oral cavity and oral cavity. There are several reports on the intervention of cleaning management in the short term and in the long term. In order to protect the rights and interests of the elderly, we must establish a system of social security. At the time of cleaning instruction and cleaning instruction, the number of bacterial species (CFU/ml) was determined at 1, 3, 6, 9 and 12 months after the tooth was installed. At each time point, the mucosal surface of the tooth around the incisor nipple, the mucosa of the mouth flap, and the oral fluid under the tooth were collected. After the culture, the number of bacterial species (CFU/ml) was determined. The presence or absence of oral cavity defects on the oral mucosa surface, the correlation factors, the correlation factors, the age, sex, the number of previous diseases, the number of commonly used drugs, the amount of saliva secretion at rest, the occurrence of oral dryness (classification of persimmon trees), the presence or absence of oral cavity defects, the presence or absence of mandibular cavity defects, the cleaning status of oral cavity defects, the presence or absence of oral cavity defects when oral cavity defects are installed, the number of bacteria in oral cavity, the humidity in oral cavity, There is a difference between the two groups. The results were published in Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. In the future, the study will focus on the development of oral cavity disease, and the study will focus on the development of oral cavity disease

项目成果

Clinical study of risk factors for adherence of Candida to dentures

假牙假牙粘附念珠菌危险因素的临床研究

• DOI: 10.1016/j.ajoms.2022.02.010
• 发表时间: 2022
• 期刊: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
• 作者: Ozaki Kimiya;Okada Kazutaka;Matsushita Takae;Kondoh Miyoko;Arai Eri;Miura Kazuhito;Baba Haruhisa;Watanabe Yutaka;Yamazaki Yutaka
• 通讯作者: Yamazaki Yutaka